Expanding the synthesis of new trans-sulfonamide platinum complexes: Cytotoxicity, SAR, fluorescent cell assays and stability studies.

Expanding the synthesis of new trans-sulfonamide platinum complexes: Cytotoxicity, SAR, fluorescent cell assays and stability studies.
J Inorg Biochem. 2013 Feb 8;
Authors: Del Solar V, Quiñones-Lombraña A, Cabrera S, Padrón JM, Ríos-Luci C, Alvarez-Valdés A, Navarro-Ranninger C, Alemán J
Abstract
In this manuscript, we describe the synthesis of new trans-N-sulfonamide platinum complexes and their antiproliferative activity (GI50, μM) in human solid tumors cells. The structure activity relationships (SAR), with different new synthesized complexes by variation in ligand, halogen and also in the stereochemistry of the ligand, has been studied. Solubility and stability studies have also been carried out as well as fluorescent cell assays in order to clarify the final target in the tumor cells.
PMID: 23474039 [PubMed - as supplied by publisher]

Source: Journal of Inorganic Biochemistry - February 8, 2013 Category: Biochemistry Authors: Del Solar V, Quiñones-Lombraña A, Cabrera S, Padrón JM, Ríos-Luci C, Alvarez-Valdés A, Navarro-Ranninger C, Alemán J Tags: J Inorg Biochem Source Type: research