Invalidation of Parkinson's disease diagnosis after years of follow-up based on clinical, radiological and neurophysiological examination

Diagnosis of Parkinson's disease (PD) is mainly based on clinical features. Accurate neurological examination is required but dopamine transporter (DaT) single photon emission computed tomography (SPECT) could be perfomed to support the diagnosis in ambiguous cases. The aim of this work is to describe the characteristics of patients with a prolonged PD misdiagnosis.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research

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AbstractBackgroundA cerebrospinal fluid (CSF)-mask algorithm has been developed to reduce the adverse influence of CSF-low-counts on the diagnostic utility of the specific binding ratio (SBR) index calculated with Southampton method. We assessed the effect of the CSF-mask algorithm on the diagnostic performance of the SBR index for parkinsonian syndromes (PS), including Parkinson ’s disease, and the influence of cerebral ventricle dilatation on the CSF-mask algorithm.MethodsWe enrolled 163 and 158 patients with and without PS, respectively. Both the conventional SBR (non-CSF-mask) and SBR corrected with the CSF-mask ...
Source: EJNMMI Research - Category: Radiology Source Type: research
Publication date: Available online 19 August 2019Source: NeuroImage: ClinicalAuthor(s): Yashar Zeighami, Seyed-Mohammad Fereshtehnejad, Mahsa Dadar, D. Louis Collins, Ronald B. Postuma, Alain DagherAbstractBackgroundCommonly used neuroimaging biomarkers in Parkinson's disease (PD) are useful for diagnosis but poor at predicting outcomes. We explored whether an atrophy pattern from whole-brain structural MRI, measured in the drug-naïve early stage, could predict PD prognosis.Methods362 de novo PD patients with T1-weighted MRI (n = 222 for the main analysis, 140 for the validation analysis) were recruited from the P...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Rapid eye movement sleep behavior disorder is a parasomnia characterized by symptoms of dream enactment and loss of muscle atonia during rapid eye movement sleep. Mild motor impairment is present in some patients with rapid eye movement sleep behavior disorder and it is presumed to be a risk factor for conversion to synucleinopathies. The purpose of this study was to identify patients with mild motor impairment by evaluating finger tapping and to investigate its pathophysiology. Twenty-three patients with rapid eye movement sleep behavior disorder and 20 healthy control subjects were recruited in this study. We accurately ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
AbstractPurposePrevious studies in patients with Parkinson ’s disease (PD) and impulse control disorders (ICDs) have produced heterogeneous results regarding striatal dopamine transporter (DaT) binding and activity in the mesocorticolimbic network. Our aim here was to study the relationship between striatal DaT availability and cortical metabolism, as wel l as motor, behavioural and cognitive features of PD patients with ICD.MethodsIn a group of PD patients with ICD (PD-ICD,n = 16) and 16 matched PD patients without ICD (PD-noICD,n = 16), DaT single-photon emission computed tomography (SPE...
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Conclusions: This study demonstrated that the classification performance of FT and FE for diagnosis of PD and NC. FT indicated more accurate diagnostic performance than that of FE. Therefore, FT has a high potential to construct automatic diagnosis system for 123-I FP-CIT dopamine transporter SPECT images.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Data Sciences Posters Source Type: research
Conclusions: We proposed the new quantitative index "f-DTV" on DAT SPECT. It was strongly correlated with SBR and had a high diagnostic ability for differentiating PD from non-PD. F-DTV can evaluate both the volume and degree of active dopamine transporter at once, making it a useful marker in Parkinson syndrome.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Technologist Posters Source Type: research
Conclusion Taken together, evidence from animal and human studies demonstrates that the brain detects levels of circulating nutrients and hormones and consequently organizes an outward response that contributes to the regulation of whole-body glucose homeostasis. However, there are major knowledge gaps about the exact nature of this response and its relative importance compared to peripheral processes. As we have seen, animal studies have provided an anatomical map of CNS glucose regulation and have identified important neurons and neural circuits involved. Additionally, the CNS sensing of key nutrients and hormones has b...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Grand Total EEG Score Can Differentiate Parkinson's Disease From Parkinson-Related Disorders Ela Austria Barcelon1,2*, Takahiko Mukaino1, Jun Yokoyama1, Taira Uehara2, Katsuya Ogata2, Jun-ichi Kira1 and Shozo Tobimatsu2 1Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan2Department of Clinical Neurophysiology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Background: Semi-quantitative electroencephalogram (EEG) analysis is easy to perform and has been used to differentiate dementias, as well ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusions The treatment used for PD, particularly DA, is associated with the development of ICDs and related behaviors. Susceptibility to these disorders depends on the associated risk factors. ICDs can have serious personal, family, psychosocial, financial, and medical consequences. However, in contrast, artistic activities have been described in patients with PD while undergoing treatment with DA. These patients are compulsive but report a positive influence on quality of life. These findings highlight the need for a very critical approach at the moment of Dopaminergic Replacement therapy choice. Author Contributio...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
This study aimed to investigate white matter microstructure alterations by using connectometry in patients with PD-EDS, in comparison to PD-nEDS and healthy individuals. Materials and Methods Participants Participants involved in this research were recruited from Parkinson's Progression Markers Initiative (PPMI, http://www.ppmi-info.org/). The study was approved by the institutional review board of all participating sites in Europe, including Attikon University Hospital (Greece), Hospital Clinic de Barcelona and Hospital Universitario Donostia (Spain), Innsbruck University (Austria), Paracelsus-Elena Clinic Kass...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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