IL-1 β-primed Mesenchymal Stromal Cells improve epidermal substitute engraftment and wound healing via MMPs and TGF-β1

Since the 1980s, deep and extensive skin wounds and burns are treated with autologous Split-Thickness Skin Grafts, or Cultured Epidermal Autografts (CEAs) when donor sites are limited. However, the clinical use of CEAs often remains unsatisfactory due to poor engraftment rates, altered wound healing and reduced skin functionality.In the past few decades, Mesenchymal Stromal Cells (MSCs) have raised much attention due to their anti-inflammatory, pro-trophic and pro-remodeling capacities. More specifically, gingival MSCs have been shown to possess enhanced wound healing properties compared to other tissue sources.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research

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Publication date: Available online 20 October 2019Source: BurnsAuthor(s): Luiz Philipe Molina Vana, Cláudia Naves Battlehner, Marcelo Alves Ferreira, Elia Garcia Caldini, Rolf Gemperli, Nivaldo AlonsoAbstractThe advent of dermal regeneration templates has fostered major advances in the treatment of acute burns and their sequelae, in the last three decades. Both data on morphological aspects of the newly-formed tissue, and clinical trials comparing different templates, are few. The goal of this study was to prospectively analyze the outcome of randomized patients treated with two of the existing templates, followed b...
Source: Burns - Category: Dermatology Source Type: research
Publication date: Available online 16 April 2019Source: BurnsAuthor(s): Monica Iliescu Nelea, Laurence Paek, Lan Dao, Nathalie Rouchet, Johnny I. Efanov, Coeugniet Édouard, Michel A. DaninoAbstractBiofilm forms when bacteria surrounded by an extracellular matrix aggregate on a surface. It can develop on many surfaces, including wound dressings; this can be particularly nefarious for burn patients undergoing skin grafting (autograft) for burn wound coverage as they often suffer from compromised immune system function. Autograft donor sites are particularly vulnerable to biofilm formation; as such, timely healing of t...
Source: Burns - Category: Dermatology Source Type: research
In conclusion, digestion time appeared to affect the isolated cells more than the choice of enzyme. PMID: 30983404 [PubMed - as supplied by publisher]
Source: Cell Transplantation - Category: Cytology Authors: Tags: Cell Transplant Source Type: research
Conclusions Lymphatic vessels, like blood vessels, are a highly interactive surface for cells of the immune system, and through the use of chemokines and their receptors can coordinate key interactions. These pathways can control the entry and function of particular immune subsets in a number of pathological conditions. Nonetheless LECs have distinct patterns of chemokine secretion and expression of chemokine receptors that distinguish them from the blood vessel system and mediate distinct roles and responses. The abundance and diversity of the chemokine family point to the likelihood that a plethora of novel chemokine fu...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: Bearing in mind the successful results of the native Pintucci KPro in this case of severe acid burn, using this type of keratoprosthesis in patients with total limbal stem cell deficiency and severe dry eye is recommended. PMID: 30820295 [PubMed]
Source: Journal of Ophthalmic and Vision Research - Category: Opthalmology Tags: J Ophthalmic Vis Res Source Type: research
Publication date: Available online 19 December 2018Source: BurnsAuthor(s): J.H. Holmes, J.A. Molnar, J.W. Shupp, W.L. Hickerson, B.T. King, K.N. Foster, B.A. Cairns, J.E. CarterAbstractIntroductionSplit-thickness skin grafts (STSG) are the standard of care (SOC) for burns undergoing autografting but are associated with donor skin site morbidity and limited by the availability of uninjured skin. The RECELL® Autologous Skin Harvesting Device (RECELL® System, or RECELL) was developed for point-of-care preparation and application of a suspension of non-cultured, disaggregated, autologous skin cells, using 1 cm2 of...
Source: Burns - Category: Dermatology Source Type: research
Publication date: November 2018Source: Burns, Volume 44, Issue 7Author(s): Takayuki Yamamoto, Hayato Iwase, Timothy W. King, Hidetaka Hara, David K.C. CooperAbstractHalf a million patients in the USA alone require treatment for burns annually. Following an extensive burn, it may not be possible to provide sufficient autografts in a single setting. Pig skin xenografts may provide temporary coverage. However, preformed xenoreactive antibodies in the human recipient activate complement, and thus result in rapid rejection of the graft. Because burn patients usually have some degree of immune dysfunction and are therefore at in...
Source: Burns - Category: Dermatology Source Type: research
Authors: Germain L, Larouche D, Nedelec B, Perreault I, Duranceau L, Bortoluzzi P, Beaudoin Cloutier C, Genest H, Caouette-Laberge L, Dumas A, Bussière A, Boghossian E, Kanevsky J, Leclerc Y, Lee J, Nguyen MT, Bernier V, Knoppers BM, Moulin VJ, Auger FA Abstract Split-thickness skin autografts (AGs) are the standard surgical treatment for severe burn injuries. However, the treatment of patients with substantial skin loss is limited by the availability of donor sites for skin harvesting. As an alternative to skin autografts, our research group developed autologous self-assembled skin substitutes (SASSs), allo...
Source: European Cells and Materials - Category: Cytology Tags: Eur Cell Mater Source Type: research
[Image from unsplash.com]From Esaote launching its new ultrasound device to Nipro’s Infraredx launching in Japan, here are seven medtech stories we missed this week but thought were still worth mentioning. 1. Esaote launches new ultrasound devices Esaote announced in an Aug. 2 press release that it has launched its new MyLab X7, MyLab X6 and MyLab X5 ultrasound systems. The MyLab X7 offers faster and more reliable ultrasounds with intuitive usability and ergonomics. MyLab X5 has zero-click automatic that speeds up assessments and enhances image quality. 2. Bonesupport inks deal with MTF Biologics Bonesuppor...
Source: Mass Device - Category: Medical Devices Authors: Tags: 510(k) Catheters Diagnostics Food & Drug Administration (FDA) Hospital Care Imaging Regulatory/Compliance Software / IT Ultrasound Bonesupport Esaote InfraReDx Inc. ivwatch MedTech Mindshare Medical Modulated Imaging MTF Bi Source Type: news
In this study, scar development and maturation were assessed in a porcine full-thickness burn model with immediate excision and split-thickness autograft coverage. Red Duroc pigs were treated with split-thickness autografts of varying thickness: 0.026 in. (“thin”) or 0.058 in. (“thick”). Additionally, the thin skin grafts were meshed and expanded at 1:1.5 or 1:4 to evaluate the role of skin expansion in scar formation. Overall, the burn-excise-autograft model resulted in thick, raised scars. Treatment with thick split-thickness skin grafts resulted in less contraction and reduced scarring ...
Source: Burns - Category: Dermatology Source Type: research
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