S wave in ECG lead V6 predicts poor response to cardiac resynchronization therapy and long-term outcome

Cardiac resynchronization therapy (CRT) is a standard treatment for selected patients with chronic heart failure (HF). However, up to 30-50% of patients still do not respond to CRT.
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research

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Nearly one-third of heart failure (HF) patients do not respond to cardiac resynchronization therapy (CRT) despite having left bundle branch block (LBBB). The aim of the study was to investigate a novel method ...
Source: Cardiovascular Ultrasound - Category: Radiology Authors: Tags: Research Source Type: research
This article provides a review of the aforementioned mechanisms of arrhythmogenesi s in heart failure; the role and impact of HF therapy such as cardiac resynchronization therapy (CRT), including the role, if any, of CRT-P and CRT-D in preventing VAs; the utility of both non-invasive parameters as well as multiple implant-based parameters for telemonitoring in HF; and the effect o f left ventricular assist device implantation on VAs.
Source: Journal of Interventional Cardiac Electrophysiology - Category: Cardiology Source Type: research
Exercise training is a well-established therapy for heart failure (HF) patients recommended in the European Society of Cardiology (ESC) HF guidelines [1]. The last Cochrane Library Review about “Exercise-based cardiac rehabilitation for adults with heart failure” underlined the important benefits of exercise-based rehabilitation that include a reduction in the risk of overall hospital admissions in the short term, as well as a potential improvement of all-cause mortality in the long te rm (>12 months follow up) [2].
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
CONCLUSIONS: Ss is an important factor affecting the response to cardiac resynchronization therapy. Patients with heart failure associated with Ss
Source: Clinics - Category: General Medicine Source Type: research
Abstract Cardiac disease is a leading cause of death worldwide. Disturbance in the conduction system of the heart may trigger or aggravate heart dysfunction, affecting the efficiency of the heart, and lead to heart failure or cardiac arrest. Patients may require implantable cardiac rhythm management devices (ICRMDs) to maintain or restore the heart rhythm. ICRMDs have undergone important improvements, yet limitations still exist, presenting important technological challenges. Most ICRMDs consist of a subcutaneous control unit and intracardiac electrodes. The leads, which connect the electrodes to the control unit,...
Source: Annals of Biomedical Engineering - Category: Biomedical Engineering Authors: Tags: Ann Biomed Eng Source Type: research
AbstractAimsIron deficiency is common in heart failure with reduced ejection fraction (HFrEF). In patients with cardiac resynchronization therapy (CRT), it is associated with a diminished reverse remodelling response and poor functional improvement. The latter is partially related to a loss in contractile force at higher heart rates (negative force –frequency relationship).Methods and resultsThe effect of intravenous ferric carboxymaltose on reverse remodelling following cardiac resynchronization therapy (IRON ‐CRT) trial is a multicentre, prospective, randomized, double‐blind controlled trial in HFrEF patients w...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Study Design Source Type: research
ConclusionIn the present study, 38% of those who remained symptomatic 6  months after CRT implantation were eligible for optimization of medical therapy with sacubitril/valsartan, ivabradine, or both. Patients with CRT may benefit from systematic follow-up including evaluation of medical treatment.Graphic abstract
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research
ConclusionCRT provides metaboreflex sensitization and MSNA enhancement. The restoration of sympathetic responsiveness correlates with the improvement in functional capacity.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: PHYSIOLOGIC PACING Source Type: research
Authors: Shah BR, DerSarkissian M, Tsintzos SI, Xiao Y, May D, Lu X, Kinrich D, Davis E, Lefebvre P, Duh MS, Dasta JF Abstract OBJECTIVE: The purpose of this study is to assess the real-world impact of cardiac resynchronization therapy (CRT) on adherence to heart failure (HF) medications. METHODS: MarketScan® administrative health care claims data from 2008 to 2014 among patients with HF were used. The date of first CRT implantation served as the index date. Adherence to guideline-directed medical therapy (GDMT) classes were compared during pre- and post-index periods using proportion of days covered (PDC). Com...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Cardiac resynchronization therapy (CRT) via bi-ventricular pacing has demonstrated clinical benefits in heart failure (HF) patients with ventricular dyssynchrony. Other approaches of CRT is little known.
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research
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