Synthesis, antimicrobial activity, and determination of the lipophilicity of ((cyclohex-3-enylmethylene)hydrazinyl)thiazole derivatives

AbstractSynthesis and investigation of antimicrobial activity of fifteen novel thiazoles containing cyclohexene moiety are presented. Among the derivatives, compounds3a–3d, 3f, 3n, and3o showed very strong activity against the referenceCandida spp. strains with MIC  = 0.015–3.91 µg/ml. The activity of these compounds is similar and even higher than the activity of nystatin used as positive control. Compounds3d,3f,3n,3o showed the highest activity with very strong effect towards most of yeasts isolated from clinical materials with MIC  = 0.015–7.81 µg/ml. The cytotoxicity studies for the most active compounds showed thatCandida spp. growth was inhibited at noncytotoxic concentrations for the mammalian L929 fibroblast. In addition, a good correlation was obtained between lipophilicity of compounds determined using reversed phase thin-layer chromatography and their antifungal activity.

Source: Medicinal Chemistry Research - September 8, 2019 Category: Chemistry Source Type: research