Regenerative Materials for Surgical Reconstruction: Current Spectrum of Materials and a Proposed Method for Classification

Chronic wound management is an enormous economic strain and quality-of-life issue for patients. Current treatments are ineffective or expensive and invasive. Materials (native and artificial) can act as the basis to enhance wound repair but often fall short of complete healing. The therapeutic index of materials have often been enhanced by combining them with drug or biologic elution technologies. Combination of materials with living drugs (cells) presents a new paradigm for enhancing therapy. Cell material interaction and therapeutic output will depend on variables ascribed to the living drug as well as variables ascribed to the underlying matrix.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Review Source Type: research

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Smith &Nephew is taking a deeper dive into the regenerative medicine market through its $660 million acquisition of Osiris Therapeutics. The London-based company said it hopes to close the deal in 2Q19 and made the announcement of the pending merger at the American Academy of Orthopedics Annual Meeting held this week in Las Vegas. Columbia MD-based Osiris Therapeutics delivered revenue of $102 million for the nine-months ended 30 September 2018, an 18.7% increase over the comparable period in 2017. Revenue was $36.5 million for the three-month period ended 30 September 2018, a 22.4% increase year on year. Osiris is exp...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Orthopedics Source Type: news
Biomaterials in regenerative medicine are designed to mimic and modulate tissue environments to promote repair. Biologic scaffolds (derived from decellularized tissue extracellular matrix) promote a wound-healing (proregenerative) immune phenotype and are used clinically to treat tissue loss, including in the context of tumor resection. It is unknown whether a biomaterial microenvironment that encourages tissue formation may also promote tumor development. We implanted a urinary bladder matrix (UBM) scaffold, which is used clinically for wound management, with syngeneic cancer cell lines in mice to study how wound-healing ...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
Pérola de Oliveira Magalhães The use of natural oils in topical pharmaceutical preparations has usually presented safe agents for the improvement of human health. Based on research into the immense potential of wound management and healing, we aimed to validate the use of topical natural products by studying the ability of the essential oil of Eugenia dysenterica DC leaves (oEd) to stimulate in vitro skin cell migration. Skin cytotoxicity was evaluated using a fibroblast cell line (L929) by MTT assay. The oil chemical profile was investigated by GC-MS. Moreover, the inhibition of lipopolysaccharide (LPS...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Publication date: Available online 23 November 2018Source: European Polymer JournalAuthor(s): Aishwarya Satish, R. Aswathi, J. Caroline Maria, Purna Sai KorrapatiAbstractChronic wound management is challenging and is further intensified due to its increasing prevalence attributed to escalation of ailments like diabetes. Presence of exudates further sustains the chronicity and is a significant burden for the healthcare sector. In this work, a wound dressing material has been formulated in the form of a lyophilized hydrogel comprising of alginate, gelatin and polyvinyl alcohol, with an aim to absorb exudates, maintain a mois...
Source: European Polymer Journal - Category: Chemistry Source Type: research
CONCLUSIONS: In conjunction with plastic surgeons, the orthopaedic team utilized LAFA for debridement that led to both a successful wound repair and skin grafting procedure. PMID: 30312970 [PubMed - in process]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
Publication date: December 2018Source: Wound Medicine, Volume 23Author(s): Mario Migliario, Filippo RenòAbstractRapid and efficient wound healing response is essential to maintain whole organism integrity and homeostasis. Such process could be influenced by a plethora of factors that when interfering with the different healing phases finally result in impaired tissue repair. Furthermore, defective healing process is often associated with chronic and difficult to heal wounds, both conditions deeply affecting patients’ quality of life.Advanced wound management solutions are the new standard in difficult to heal ...
Source: Wound Medicine - Category: General Medicine Source Type: research
Publication date: Available online 14 September 2018Source: Wound MedicineAuthor(s): Mario Migliario, Filippo RenòAbstractRapid and efficient wound healing response is essential to maintain whole organism integrity and homeostasis. Such process could be influenced by a plethora of factors that when interfering with the different healing phases finally result in impaired tissue repair. Furthermore, defective healing process is often associated with chronic and difficult to heal wounds, both conditions deeply affecting patients’ quality of life.Advanced wound management solutions are the new standard in difficul...
Source: Wound Medicine - Category: General Medicine Source Type: research
Abstract Giving a glance to the report Wound Care Market by Product up-to-date at 2017, we can see that wound care market is expected to reach USD 22.01 billion by 2022 from USD 18.35 billion at a CAGR of 3.7%. Numerous are the factors driving the growth of this market, including the increasing prevalence of chronic wounds and acute wounds, increasing aged population, rising R&D activities and advancement in the field of wound care research. Advanced wound management products are accounted for the largest market share in 2017. These evidences meaning that the wound care research represents a Clinical Emergency oth...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
Authors: Sabo M, Le L, Yaakov RA, Carter M, Serena TE Abstract Chronic wounds (ie, wounds that fail to progress through a normal, orderly, timely sequence of repair) continue to pose significant clinical and economic burdens. A prospective, descriptive, 3-week post-marketing surveillance study was conducted across 3 wound care centers in the United States to evaluate the effectiveness of a collagen calcium alginate dressing on chronic wounds in conjunction with standard care (SC) practices (eg, offloading, debridement, compression) to support healing. Eligible participants had to be>18 years of age, have at leas...
Source: Ostomy Wound Management - Category: Surgery Tags: Ostomy Wound Manage Source Type: research
Abstract This single‐center prospective, controlled observational study investigates the impact of incisional negative pressure wound therapy on wound healing processes and its potency to prevent superficial surgical site infections (SSSI) after reversal of a double loop ileostomy. Furthermore, this study gains insight in socioeconomic aspects, like duration of hospital stay and, for the first time, patient's quality of life during the incisional negative pressure wound treatment. To address this question, an interventional group of 24 patients treated with incisional negative pressure wound therapy (Prevena incisional w...
Source: Wound Repair and Regeneration - Category: Surgery Authors: Tags: Original Research ‐Clinical Science Source Type: research
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