What ’s new in adipocytic neoplasia?

AbstractAdipocytic tumors are frequently encountered in routine practice, and while the vast majority represent commonly encountered tumor types (e.g., benign lipoma), the heterogeneity and rarity of other adipocytic neoplasms can pose diagnostic challenges. Atypical and malignant adipocytic tumors account for approximately 20% of all sarcomas. The 2013 World Health Organization (WHO) classification of soft tissue and bone tumors recognizes four major liposarcoma subtypes, characterized by distinct clinical behavior, distinctive morphologies, as well as unique genetic findings: atypical lipomatous tumor/well-differentiated liposarcoma, dedifferentiated liposarcoma, myxoid liposarcoma, and pleomorphic liposarcoma. Since the publication of the 2013 WHO classification of soft tissue and bone tumors, the most notable change in the category of adipocytic tumors has been made in the clinicopathologic and molecular characterization of the heterogeneous but distinct group of “atypical low-grade adipocytic neoplasms with spindle cell features,” for which the term atypical spindle cell/pleomorphic lipomatous tumor has been proposed. Another substantive change in the group of adipocytic tumors is the introduction of pleomorphic myxoid liposarcoma (myxoid pleomorphic li posarcoma) as an apparently novel subtype of aggressive liposarcoma, especially occurring in children and young adults with a predilection for the mediastinum. This review will further focus upon the diagnosti...
Source: Virchows Archiv - Category: Pathology Source Type: research

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Authors: Malinauskaite I, Hofmeister J, Burgermeister S, Neroladaki A, Hamard M, Montet X, Boudabbous S Abstract Distinguishing lipoma from liposarcoma is challenging on conventional MRI examination. In case of uncertain diagnosis following MRI, further invasive procedure (percutaneous biopsy or surgery) is often required to allow for diagnosis based on histopathological examination. Radiomics and machine learning allow for several types of pathologies encountered on radiological images to be automatically and reliably distinguished. The aim of the study was to assess the contribution of radiomics and machine learn...
Source: Sarcoma - Category: Cancer & Oncology Tags: Sarcoma Source Type: research
CONCLUSIONS: Currently, there is no evidence-based recommendation available regarding the management of lipomas detected during open or laparoscopic inguinal hernia surgery. Due to the extremely low risk of the presence of a liposarcoma routine histologic examination cannot be recommended unless the diameter exceeds 10 cm. PMID: 31690184 [PubMed - as supplied by publisher]
Source: Acta Chirurgica Belgica - Category: Surgery Tags: Acta Chir Belg Source Type: research
Abstract Lipid droplets, a morphological feature of adipocytic tumors, are strongly regulated by associated proteins of the perilipin/PAT-family. So far, the use of perilipins as markers for differential diagnosis of soft tissue tumors has only been studied in a few cases. The aim of the study was to investigate the expression of perilipins in 478 human soft tissue tumors as well as 60 respective normal tissues. All cases of well differentiated liposarcoma, over 90% of myxoid round cell liposarcoma and over 70% of pleomorphic liposarcoma, yet only in the well differentiated components of dedifferentiated liposarco...
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research
A RARE CASE OF GIANT INTRAPERITONEAL LIPOMA IN PATIENT WITH NODULAR FASCIITIS: IMAGE 18F-FDG PET / CT. J Nucl Med Technol. 2019 Apr 24;: Authors: Ibañez Ibañez MJ, Reyes Marles RR, Frutos Esteban L, Claver Valderas MA Abstract Nodular fasciitis is a benign reactive proliferation of myofibroblasts but sometimes misdiagnosed as sarcoma based on cellularity, mitotic figures and rapid growth. On the other hand, giant intraperitoneal lipomas are very rare cases and most of them are reported as liposarcoma because their large size; although liposarcoma is only 0.1% of all human neoplasms, is th...
Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research
CONCLUSION: Musculoskeletal tumors are rare, but descriptive data in any region are important in order to reduce mortality and improve treatment. No significant difference was found between the data of our hospital regarding epidemiology of the musculoskeletal system tumors and those from the other regions around the world. LEVEL OF EVIDENCE: Level IV, Therapeutic study. PMID: 30982757 [PubMed - as supplied by publisher]
Source: Acta Orthopaedica et Traumatologica Turcica - Category: Orthopaedics Authors: Tags: Acta Orthop Traumatol Turc Source Type: research
ConclusionKnowledge of the anatomy, and the spectrum of imaging findings of common and uncommon benign and malignant neoplasms of the ischiorectal fossa is crucial for the radiologists during interpretation of images allowing them to make contributions to the diagnosis and better patient management.
Source: Abdominal Imaging - Category: Radiology Source Type: research
Fat containing tumors can be benign (lipomas) or malignant (liposarcomas). Liposarcomaswhich account for approximately 20% of all sarcomas comprise different degrees of malignancy, including low (well differentiated), intermediate (myxoid) and high (pleomorphic, dedifferentiated) [1]. Histologic type and grade is important to predict the clinical behavior of liposarcomas, i.e. rate of growth, possibility to metastasize, risk of recurrence and survival rate.
Source: Physica Medica: European Journal of Medical Physics - Category: General Medicine Authors: Tags: Original paper Source Type: research
Authors: Johnson CN, Ha AS, Chen E, Davidson D Abstract Lipomatous soft-tissue tumors are the most common neoplasms encountered by physicians. They range from benign lipomas to high-grade liposarcomas. Unplanned excisions of sarcomas are commonly due to the presumptive diagnosis of lipoma and can be avoided by understanding their diagnostic magnetic resonance imaging appearance. Magnetic resonance images should be obtained for all soft-tissue masses that are deep to fascia or those>5 cm in subcutaneous tissue. Atypical lipomatous tumors present as large deep fatty masses and have a propensity for local recurrenc...
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
Conclusion: The accuracy of both our readers and the formula suggests that MRI remains unreliable for distinguishing between lipoma and WDLs. PMID: 29755284 [PubMed]
Source: Sarcoma - Category: Cancer & Oncology Tags: Sarcoma Source Type: research
Authors: Fricke A, Cimniak AFV, Ullrich PV, Becherer C, Bickert C, Pfeifer D, Heinz J, Stark GB, Bannasch H, Braig D, Eisenhardt SU Abstract BACKGROUND: Liposarcoma constitute about 13% of all soft tissue sarcoma and are associated with a high risk of metastases. As the preoperative differentiation between benign and malign lipomatous tumors is restricted to magnetic resonance imaging, computed tomography and biopsy, we performed a miRNA array to distinguish dedifferentiated liposarcoma patients from healthy controls and lipoma patients. METHODS: Blood samples of patients with dedifferentiated liposarcoma, heal...
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
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