Long-term treatment with 3,4-methylenedioxymethamphetamine caused retina damage in C57BL/6 mice

Conclusions: These results suggest that long-term treatment with methylenedioxymethamphetamine increases inflammatory responses in photoreceptor cells resulting in retinal dysfunction in C57BL/6 mice. Thus, this investigation provides preclinical rationale for the retina damage caused by the methylenedioxymethamphetamine abuse.RESUMO Objetivos: Como uma classe de drogas psicoesti mulantes, as anfetaminas s ão amplamente usadas por suas propriedades estimulantes, eufóricas e alucinógenas. Muitos desses efeitos resultam de aumentos agudos na neurotransmissão da dopamina e da serotonina. Após o início desses efeitos, a 3,4-metilenedioximetanfetamina produz danos persistentes nos terminais nervosos de dopamina e serotonina, resultando em neurotoxicidade duradoura. O objetivo desta investigação foi avaliar os efeitos do tratamento baixa dose de metilenedioximetanfetamina na função da retina em camundongos C57BL/6 e seus mecanismos subjacentes. Métodos: Camundongos C57BL/6 foram divididos aleatoriamente em dois grupos (n=10): um grupo foi tratado com solução salina tamponada de fosfato por injeção intraperitoneal diária; o outro grupo foi tratado com 1 mg/kg de metilenedioximetanfetamina por injeção intraperitoneal diária durante 3 meses. Eletroretinografia foi utilizada para testar a função da retina a cada mês. A coloraç&a...
Source: Arquivos Brasileiros de Oftalmologia - Category: Opthalmology Source Type: research

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Conclusion: As challenges facing the role put it at risk and healthcare becomes increasingly value based, the need for expert clinicians who can demonstrate their value becomes essential. Clinical nurse specialists and hospital leadership can benefit from exploring successful interventions to rebuild CNS teams to achieve these goals.
Source: Clinical Nurse Specialist - Category: Nursing Tags: Feature Article Source Type: research
Conclusion: By influencing a certain patient population throughout the organization, population-focused CNSs are in a unique role to lead an interprofessional team or serve as an expert consultant in pursuing DSC certification from The Joint Commission.
Source: Clinical Nurse Specialist - Category: Nursing Tags: Feature Article Source Type: research
Conclusions: Implementation of an adapted aspiration risk assessment screening tool to document risk of hospital-acquired aspiration pneumonia and aspiration precautions protocol was associated with a decrease in aspiration pneumonia rates.
Source: Clinical Nurse Specialist - Category: Nursing Tags: Feature Article Source Type: research
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Source: Clinical Nurse Specialist - Category: Nursing Tags: DEPARTMENTS: Educator’s Corner Source Type: research
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Source: Clinical Nurse Specialist - Category: Nursing Tags: DEPARTMENTS: Nursing and the Arts Source Type: research
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