IL-27 posttranslationally regulates Y-box binding protein-1 to inhibit HIV-1 replication in human CD4+ T cells

Conclusion:
IL-27-pretreatment inhibits HIV-1 infection by suppressing an HIV-reverse transcription product formation/uncoating step by suppressing the acetylation of YB-1 in primary CD4+ T cells.

Source: AIDS - September 9, 2019 Category: Infectious Diseases Tags: BASIC SCIENCE Source Type: research