Magnesium sulfate inhibits inflammation through P2X7 receptors in human umbilical vein endothelial cells.

CONCLUSION: LPS-exposure increases IL-1β production and secretion in HUVECs, which is further intensified by P2X7R agonist, BzATP while MgSO4 inhibits IL-1β in both presence and absence of BzATP. This effect is similar to the results of P2X7R antagonist, BBG, suggesting that the anti-inflammatory effects of MgSO4 is through P2X7R.
PMID: 31493768 [PubMed - as supplied by publisher]

Source: Pediatric Research - September 6, 2019 Category: Pediatrics Authors: Ozen M, Xie H, Shin N, Al Yousif G, Clemens J, McLane MW, Lei J, Burd I Tags: Pediatr Res Source Type: research