Leveraging early HIV diagnosis and treatment in Thailand to conduct HIV cure research.

Leveraging early HIV diagnosis and treatment in Thailand to conduct HIV cure research. AIDS Res Ther. 2019 Sep 06;16(1):25 Authors: Muccini C, Crowell TA, Kroon E, Sacdalan C, Ramautarsing R, Seekaew P, Phanuphak P, Ananworanich J, Colby DJ, Phanuphak N Abstract Thailand has the highest prevalence of HIV among countries in Asia but has also been a pioneer in HIV prevention and treatment efforts in the region, reducing the incidence of new infections significantly over the last two decades. Building upon this remarkable history, Thailand has set an ambitious goal to stop the AIDS epidemic in the country by 2030. A key component of the strategy to achieve this goal includes scale-up of HIV screening programs to facilitate early HIV diagnosis and investment in mechanisms to support immediate initiation of antiretroviral therapy (ART). Initiation of ART during early or acute HIV infection not only reduces viremia, thereby halting onward transmission of HIV, but also may facilitate HIV remission by reducing the size of the latent HIV reservoir and preserving immune function. In Thailand, many efforts have been made to reduce the time from HIV infection to diagnosis and from diagnosis to treatment, especially among men who have sex with men and transgender women. Successfully identifying and initiating ART in individuals with acute HIV infection has been leveraged to conduct groundbreaking studies of novel strategies to achieve HIV remission, including studies...
Source: AIDS Research and Therapy - Category: Infectious Diseases Authors: Tags: AIDS Res Ther Source Type: research

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A 25 year-old tuberculosis patient is treated at her home in Funafuti, the main island of Tuvalu in the South Pacific. Credit: UNDP Tuvalu/Aurélia Rusek.By External SourceUNITED NATIONS, Oct 17 2019 (IPS) A staggering 1.5 million people died from tuberculosis (TB) last year, the UN health agency said on Thursday, in an appeal for far greater funding and political support to eradicate the curable and preventable disease. Caused by the bacteria Mycobacterium tuberculosis, TB commonly causes persistent coughing, fatigue and weight loss. According to the World Health Organization (WHO) and its latest Global TB Report, a...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Global Headlines Health Poverty & SDGs Source Type: news
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Condition:   Ebola Virus Disease Intervention:   Drug: Ad26.ZEBOV/MVA-BN-Filo Sponsors:   MRC/UVRI Uganda Research Unit on Aids;   Epicentre, Paris, France and Mbarara, Uganda;   Janssen Pharmaceutica N.V., Belgium;   Coalition for Epidemic Preparedness Innovations Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract The rising prevalence of HIV drug resistance (HIVDR) could threaten gains made in combating the HIV epidemic and compromise the 90-90-90 target proposed by United Nations Programme on HIV/AIDS (UNAIDS) to have achieved virological suppression in 90% of all persons receiving antiretroviral therapy (ART) by the year 2020. HIVDR has implications for the persistence of HIV, the selection of current and future ART drug regimens, and strategies of vaccine and cure development. Focusing on drug classes that are in clinical use, this Review critically summarizes what is known about the mechanisms the virus utiliz...
Source: Cell Host and Microbe - Category: Microbiology Authors: Tags: Cell Host Microbe Source Type: research
Conclusion: After thorough investigation of this strategy, we have identified key considerations for the development of a chemically contiguous heroin–fentanyl vaccine. Importantly, this is the first report of such a strategy in the opioid–drug–vaccine field. Beilstein J. Org. Chem. 2019, 15, 1020–1031. doi:10.3762/bjoc.15.100
Source: Beilstein Journal of Organic Chemistry - Category: Chemistry Authors: Tags: antinociception fentanyl hapten heroin vaccine Full Research Paper Source Type: research
Conclusion: The Mtb infection status had a significant impact on mycobacterial growth inhibition in PBMC from healthy adults in South Korea, a country with an intermediate burden of tuberculosis, with healthy controls showing the greatest mycobacterial growth inhibition. Introduction Pulmonary tuberculosis (TB) is an airborne infectious disease caused by Mycobacterium tuberculosis (Mtb), which is a significant burden for the world, reaching 9.6 million new TB cases and 1.5 million deaths per year (1). Also, just under a quarter of the global population is latently infected with Mtb, and 5–10% of them will dev...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Yuka Nadai1,2, Kathrin Held1,2, Sarah Joseph3, Mohamed I. M. Ahmed1,2, Verena S. Hoffmann1,2, David Peterhoff4, Marco Missanga5, Asli Bauer1,5, Agricola Joachim6, Ulf Reimer7, Johannes Zerweck7, Sheena McCormack3, Alethea V. Cope8, Roger Tatoud8, Robin J. Shattock8, Merlin Lee Robb9, Eric G. Sandstroem10, Michael Hoelscher1,2, Leonard Maboko5, Muhammad Bakari6, Arne Kroidl1,2, Ralf Wagner4,11, Jonathan Weber8, Georgios Pollakis12 and Christof Geldmacher1,2* 1Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, Germany 2German Center for Infection Research (DZIF), Partner S...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study has several limitations. Frist, HCV exists in a quasispecies form in human body (Martell et al., 1992). It will be better to obtain a single full-length genome sequence from a single virus. However, because of failure in amplification of near full-length HCV genome (>5000 bps), we amplified and sequenced 10 overlapping HCV genomic segments to obtain the whole genome sequence. Therefore, the genomic sequences obtained in this study contain some ambiguous (or degenerate) nucleotides (quasispecies population). Second, previous studies showed that vast majority of IDUs in Yunnan, especially in the China-Myanmar b...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Jeffrey G. Shaffer1*, Frances J. Mather1, Mamadou Wele2, Jian Li1, Cheick Oumar Tangara2, Yaya Kassogue2, Sudesh K. Srivastav1, Oumar Thiero2, Mahamadou Diakite2, Modibo Sangare2, Djeneba Dabitao2, Mahamoudou Toure2, Abdoulaye A. Djimde2, Sekou Traore2, Brehima Diakite2, Mamadou B. Coulibaly2, Yaozhong Liu1, Michelle Lacey3, John J. Lefante1, Ousmane Koita2, John S. Schieffelin4, Donald J. Krogstad1 and Seydou O. Doumbia2 1Department of Global Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States 2Faculty of Medicine and Odontostomatology, Un...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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