Comparisons of the clinical outcomes between early- and adult-onset bipolar disorders: a prospective cohort analysis - Liu SK, Chang JC, Tsai HJ, Wu CS.

This study aimed to explore the impact of age-at-onset on clinical outcomes in bipolar-spectrum disorders, including the development of alcohol or substance use disorder, suicidality, and psychiatric hospitalization. METHODS: This popul...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

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Are you always in control and always perfectly put together? Are you professionally successful, a great friend, and always showing a happy face to the world?  But what about on the inside? Is there something in the background or in the past that you don’t talk about?  Do you feel disconnected, like no one knows the “real” you? Deep down do you just know something is wrong? Well, you might have “perfectly hidden depression.” Today Gabe speaks with Dr. Margaret Rutherford who has done extensive work on the relationship between perfectionism and depression.  Dr. Rutherford tells u...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior Depression General Happiness Interview LifeHelper Mental Health and Wellness Perfectionism Personality Podcast Psychiatry Psychology Research Self-Esteem Self-Help The Psych Central Show Trauma Source Type: blogs
In this study we aimed to evaluate the pleiotropic nature of SLC6A4 alterations and their association with the overall risk of brain diseases rather than disorder-specific. SLC6A4 variants, namely 5HTTLPR, STin2, rs2066713, rs25531, rs4251417, rs6354 and rs7224199 were investigated in 4 independent cohorts of subjects with specific psychiatric disorders, including Alcohol dependence disorder (ALC), Alzheimer disease (ALZ), Schizophrenia (SCZ) and Bipolar disorder (BPD). Other variables (biochemical parameters and Psychiatric scales scores) were also tested for association. SLC6A4 polymorphisms are not associated with the r...
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
Publication date: Available online 27 September 2019Source: Brain, Behavior, and ImmunityAuthor(s): Jane Pei-Chen Chang, Kuan-Pin SuAbstractThe ‘monoamine hypothesis’ is insufficient in approaching the aetiology of psychiatric disorders or in developing novel therapies. Accumulating evidence suggests that inflammatory regulation plays an important role in pathophysiology and therapeutic mechanism across the major psychiatric disorders. “Inflammation theory” might not be the full answer for the big picture of mental disorders, but it might explain high occurrence of somatic symptoms and comorbidity o...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Abstract The 'monoamine hypothesis' is insufficient in approaching the aetiology of psychiatric disorders or in developing novel therapies. Accumulating evidence suggests that inflammatory regulation plays an important role in pathophysiology and therapeutic mechanism across the major psychiatric disorders. "Inflammation theory" might not be the full answer for the big picture of mental disorders, but it might explain high occurrence of somatic symptoms and comorbidity of physical illness in certain subtypes of the heterogeneous groups. Due to the complexity of clinical manifestations and bio-psycho-soci...
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Tags: Brain Behav Immun Source Type: research
ConclusionOur panoramic meta-overview suggests that exercise can be an effective adjunctive treatment for improving symptoms across a broad range of mental disorders.
Source: Sports Medicine - Category: Sports Medicine Source Type: research
CONCLUSIONS: The current findings highlight the importance of addressing opioid use disorders and alcohol use disorders and depression together to mitigate the risk of suicidal behavior. PMID: 31522694 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
CONCLUSION: Metabolic syndrome is associated with low-grade inflammation and may act as a risk factor and a trait marker for affective disorders. If confirmed in longitudinal studies, this suggests the importance of early intervention and preventive approaches targeted towards unhealthy lifestyle factors that may contribute to later psychopathology. PMID: 31482770 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
Conclusion: Natural recovery after TBI may include delayed onset of functional decline or early recovery, followed by progressive deterioration, and is negatively affected by medical comorbidities. Results contribute to the growing evidence that TBI is most appropriately treated as a chronic medical condition complicated by a variety of comorbid conditions.
Source: The Journal of Head Trauma Rehabilitation - Category: Neurology Tags: Original Articles Source Type: research
BACKGROUND: The ratio of the index finger to the ring finger (2D:4D) is a reflection of the intrauterine hormonal environment and a lower ratio has been shown to be associated with male gender, impulsive behaviors, substance abuse, and aggression. Bipolar ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Conclusions and discussionOur study showed significant associations between migraine headache and psychiatric disorders, as well as with role functioning and disability. The findings of our study emphasise the need for screening for psychiatric comorbidity among those with migraine and the development of appropriate interventions for this group.
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research
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