A Phase I Study of Alpha-1,3-Galactosyltransferase-Expressing Allogeneic Renal Cell Carcinoma Immunotherapy in Patients with Refractory Metastatic Renal Cell Carcinoma.
CONCLUSION: In pretreated mRCC, HAR immunotherapy was well tolerated and demonstrated antitumor activity. HAR immunotherapy may be a candidate for inclusion in novel combinations for salvage treatment of mRCC. PMID: 31492769 [PubMed - as supplied by publisher]
Publication date: Available online 27 February 2020Source: Preventive Veterinary MedicineAuthor(s): Ayako Ebata, Catherine Hodge, Dorien Braam, Linda Waldman, Joanne Sharp, Hayley MacGregor, Henrietta Moore
Authors: Shabataev V, Saadat SH, Elterman DS Abstract The two major long-term concerns associated with different options for the management of prostate cancer, (including surgery, radiotherapy, brachytherapy, cryotherapy, HIFU, etc.) include difficulties with lower urinary tract symptoms (LUTS) and/or erectile dysfunction. LUTS can be in the form of stress urinary incontinence (SUI), urge urinary incontinence (UUI), frequency/urgency, and/or voiding difficulties. While surgery is mostly associated with SUI and radiation mostly results in UUI, there can be an overlap. Incontinence rates after cryotherapy and high in...
Authors: Magee DE, Singal RK Abstract Our objective is to provide an up-to-date summary of current literature on the indications for androgen deprivation therapy (ADT), ways in which ADT is used, and the main side effects associated with its use. MEDLINE (Pubmed) was searched for relevant papers published from database inception to May 1, 2019 for studies evaluating the use of ADT and its associated adverse events. ADT is a mainstay in the treatment of prostate cancer and is used throughout the disease course. While predominantly used in the metastatic setting, ADT has a role in the treatment of localized disease a...
Authors: Law KW, Nguyen DD, Barkin J, Zorn KC Abstract Prostate cancer screening remains highly controversial in medicine. The College of Family Physicians of Canada currently endorses positions that recommend against prostate-specific antigen (PSA) screening in men of all ages, while the Canadian Urological Association recommends shared and informed decision making for PSA screening in men 50-70 years old. Unfortunately, these opposing stances have left Family Physicians responsible for interpreting the appropriate course of action for their patients. Recent studies demonstrating an increase in incidence of metast...
This article is categorized under: Biological Mechanisms> Metabolism Translational, Genomic, and Systems Medicine> Translational Medicine Biological Mechanisms> Cell Signaling
Contributors : Lu Xin ; Liu GuoqiangSeries Type : Expression profiling by arrayOrganism : Mus musculusMyeloid derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells with differentiation program partially blocked in pathological conditions such as cancer. Through inhibition of T cells especially cytotoxic T lymphocytes (CTLs), MDSCs play important tumor-promoting roles and maintain a state of immunological anergy and toleranceWe used microarrays to profile gene expression of Gr-MDSC and identified differentially altered genes under different drug treatment.
In this study, a versatile reduced graphene oxide (rGO) based drug delivery system (DDS) was developed for... The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/C9CC09712K, CommunicationWenna Guo, Zengzhen Chen, Longfei Tan, Xiangling Ren, Qiong Wu, Changhui Fu, Yongxing Du, Jun Ren, Xianwei Meng We design a multifunctional CDDP-VPA@ZrMOF-Cys-PEG nanoparticles (CVZP NPs) based on the properties of valproic acid (VPA) that can downregulate the expression of vascular endothelial growth factor (VEGF) to reduce the... The content of this RSS Feed (c) The Royal Society of Chemistry
Active surveillance is a widely embraced option for men with low-risk prostate cancer who wish to avoid immediate therapy and its associated morbidity.1 Unfortunately, a number of these men will harbor more aggressive disease at diagnosis that will go unrecognized and the opportunity for curative therapy may be delayed or missed altogether. The advent of multiparametric MRI in the evaluation of these men has offered better initial risk stratification. A number of recent trials have demonstrated reasonable positive predictive value in the detection of clinically significant disease.
In the present paper we reported the finding of bulbospongiosus muscle (BSM) histology in patients with bulbar urethral strictures. The histologic assessment of the blood vessels, the neural integrity and the BSM itself were analyzed. There were 2 groups of patients where tissue for analysis was harvested. The experimental group (the stricture group) with bulbar urethral stricture undergoing urethroplasty and the control group which were patients undergoing perineal urethrostomy such as hypospadias cripples, penile cancer, or infections.