Antiproliferative activity of heterometallic sodium and potassium-dioxidovanadium(V) polymers.

Antiproliferative activity of heterometallic sodium and potassium-dioxidovanadium(V) polymers. J Inorg Biochem. 2019 Aug 27;200:110811 Authors: Sutradhar M, Alegria ECBA, Ferretti F, Raposo LR, Guedes da Silva MFC, Baptista PV, Fernandes AR, Pombeiro AJL Abstract The syntheses of the heterometallic sodium and potassium-dioxidovanadium 2D polymers, [NaVO2(1κNOO';2κO"-L)(H2O)]n(1) and [KVO2(1κNOO';2κO';3κO"-L)(EtOH)]n(2) (where the κ notation indicates the coordinating atoms of the polydentate ligand L) derived from (3,5-di-tert-butyl-2-hydroxybenzylidene)-2-hydroxybenzohydrazide (H2L) are reported. The polymers were characterized by IR, NMR, elemental analysis and single crystal X-ray diffraction analysis. The antiproliferative potential of 1 and 2 was examined towards four human cancer cell lines (ovarian carcinoma, A2780, colorectal carcinoma, HCT116, prostate carcinoma, PC3 and breast adenocarcinoma, MCF-7cell lines) and normal human fibroblasts. Complex 1 and 2 showed the highest cytotoxic activity against A2780 cell line (IC50 8.2 and 11.3 μM, respectively) with 1 > 2 and an IC50 in the same range as cisplatin (IC50 3.4 μM; obtained in the same experimental conditions) but, interestingly, with no cytotoxicity to healthy human fibroblasts for concentrations up to 75 μM. This high cytotoxicity of 1 in ovarian cancer cells and its low cytotoxicity in healthy cells demonstrates its potential for further biologic...
Source: Journal of Inorganic Biochemistry - Category: Biochemistry Authors: Tags: J Inorg Biochem Source Type: research