Linear IgA Bullous Dermatosis: A Series of 17 Cases

Publication date: Available online 8 September 2019Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): M.S. Díaz, L. Morita, B. Ferrari, S. Sartori, M.F. Greco, L. Sobrevias Bonells, M.A. González-Enseñat, M.A. Vicente Villa, M. LarraldeAbstractLinear IgA bullous dermatosis is an acquired subepidermal immunoglobulin-mediated vesiculobullous disease. In this retrospective, observational, descriptive study, we describe the clinical characteristics, treatments, and outcomes of 17 patients with linear IgA bullous dermatosis. Two children had been vaccinated 2 weeks before the onset of symptoms, 2 had had bronco-obstructive respiratory symptoms, and 1 had received intravenous antibiotic therapy. We also observed an association with autoimmune hepatitis in one patient and alopecia areata in another. One boy had VACTERL association. Diagnosis was confirmed by histopathology and direct immunofluorescence. Sixteen patients were treated with dapsone, which was combined with oral corticosteroids in 8 cases and topical corticosteroids in two. Of note in this series was the occurrence of relapses in the perioral area coinciding with infections and vaccination, and the association between linear IgA bullous dermatosis and autoimmune hepatitis and VACTERL association.ResumenLa dermatosis ampollar IgA lineal es una enfermedad vesicoampollar subepidérmica, adquirida, mediada por inmunoglobulinas. Presentamos nuestra serie con el objetivo de describir las características clí...
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research