Identification of Inhibitors against Botulinum Neurotoxins: 8-Hydroxyquinolines Hold Promise.

Identification of Inhibitors against Botulinum Neurotoxins: 8-Hydroxyquinolines Hold Promise.
Mini Rev Med Chem. 2019 Sep 06;:
Authors: Chauhan R, Chauhan V, Sonkar P, Dhaked RK
Abstract
Botulinum neurotoxins (BoNTs) are the most toxic category A biological warfare agent. There is no therapeutics available for BoNT intoxication yet, necessitating the development of a medical countermeasure against these neurotoxins. The discovery of small molecule-based drugs has revolutionized in the last two decades resulting in the identification of several small molecule inhibitors of BoNTs. However, none progressed to clinical trials. 8-Hydroxyquinolines scaffold based molecules are important 'privileged structures' that can be exploited as inhibitors of a diverse range of targets. In this review, our study of recent reports suggests the development of 8-hydroxyquinoline derived molecules as a potential drug may be on the horizon.
PMID: 31490749 [PubMed - as supplied by publisher]

Source: Mini Reviews in Medicinal Chemistry - September 5, 2019 Category: Chemistry Authors: Chauhan R, Chauhan V, Sonkar P, Dhaked RK Tags: Mini Rev Med Chem Source Type: research