Antipsychotic Linked to Potentially Fatal Skin Reaction (FREE)

By Amy Orciari Herman Edited by André Sofair, MD, MPH, and William E. Chavey, MD, MS The antipsychotic ziprasidone (marketed as Geodon and generics) is associated with increased risk for drug reaction with eosinophilia and systemic symptoms (DRESS), the …
Source: Physician's First Watch current issue - Category: Primary Care Source Type: news

Related Links:

Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Source Type: research
Diabetes mellitus (DM) is a heterogeneous group of disorders characterized by persistent hyperglycemia. Its two most common forms are type 1 diabetes (T1D) and type 2 diabetes (T2D), for which genetic and environmental risk factors act in synergy. Because it occurs in children and involves infectious, autoimmune or toxic destruction of the insulin-secreting pancreatic beta-cells, type 1 diabetes has been called juvenile or insulin-deficient diabetes. In type 2, patients can still secrete some insulin but its effectiveness may be attenuated by ‘insulin resistance.’ There is also a group of rare forms of diabetes...
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
Neuroinflammation is a condition characterized by the elaboration of proinflammatory mediators within the central nervous system. Neuroinflammation has emerged as a dominant theme in contemporary neuroscience due to its association with neurodegenerative disease states such as Alzheimer's disease, Parkinson's disease and Huntington's disease. While neuroinflammation often is associated with damage to the CNS, it also can occur in the absence of neurodegeneration, e.g., in association with systemic infection.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
The topic of this Supplement on Role of Environment in Initiation and Progression of Illnesses covers the most challenging issues facing the world today in terms of pollution, climate, nutritional, behavioral and societal changes as well as their long-term and epigenetic impact on the development and progression of cardiac, metabolic, mental and neurological disorders. Air pollution affects 90% of the world's population and has become one of the most important cause of premature death. Most of the world's population lives in cities that have both health risks and benefits.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
Air pollution affects 90% of the world's population and has caused 9 million deaths in 2015, becoming the most important cause of premature deaths in the world. Exposure to fine particulate matter, a major component of urban air pollution, has been associated with an increase in cardiovascular risk and associated mortality. Impact of fine particles on the cardiovascular system includes inflammation, activation of prothrombotic pathways, oxidative stress, vascular dysfunction and remodeling, and neurological dysfunction.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
Traumatic brain injury (TBI) is a leading cause of death and disability, contributing to ~30% of all injury-related deaths in the US. TBI occurs when a force transmitted to the head causes neuropathologic damage and impairment of brain function. TBI doubles risk of suicide and is the major determinant of acquired seizure disorders. TBI arising from closed head trauma (CHT) significantly increases the risk of developing Alzheimer's disease (AD), Parkinson's disease (PD) and chronic traumatic encephalopathy (CTE).
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
The aim of this review was to identify and, particularly, to classify all the numerous environmental factors that play a significant role in the environment-dependent body weight dysregulation. The main environmental obesogenic factors are related to build environment such as city plan, transport and school, inactivity, TV and screen-related immobility, smart-phone, video games; they are followed by agroalimentary factors such as imbalanced ingredients, pollutants, speed eating, portion size, sweet drinks, nibbling and junk foods supported by publicity, sociocultural and ethnic factors beside the global environmental chang...
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
Modern biomedical scientists are often trapped in silos of knowledge and practice, such as those who study brain structure, function and behavior, on the one hand, and body systems and disorders, on the other. Scientists and physicians in each of those silos have not often paid attention to the brain-body communication that leads to multi-morbidity of systemic and brain-related disorders [eg. depression with diabetes or cardiovascular disease]. Outside of biomedicine, social scientists have long recognized the impact of the social and physical environment on individuals and populations but have not usually connected these ...
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
Most of the world's population now lives in cities. While living in cities have both health risks and benefits, mental health has been usually considered to be negatively affected by urbanicity. While mental health disorders have complex etiology and multiple causes, it has been shown in multiple observational studies that mood and anxiety disorders are more prevalent in urban centers and incidence has been increasing. In addition, the incidence of schizophrenia is strongly increased in people born and raised in cities.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
Authors: Feng X, Zhang L, Nie S, Zhuang L, Wang W, Huang J, Yan X, Meng F Abstract BACKGROUND The aim of this study was to explore the impact of Ras homolog C/Rho-associated coiled-protein kinase (Rho/ROCK) signaling pathways intervention on biological characteristics of the human multiple myeloma cell lines RPMI-8226 and U266 cells, and to investigate the expression of RhoC, ROCK1, and ROCK2 in RPMI-8226 and U266 cells. MATERIAL AND METHODS RPMI8226 and U266 cell lines were treated by 5-aza-2-deoxycytidine (5-Aza-Dc), trichostatin A (TSA), RhoA inhibitor CCG-1423, Rac1 inhibitor NSC23766, and ROCK inhibitor fasudi...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
More News: Drugs & Pharmacology | Geodon | Primary Care | Skin | Ziprasidone