Pain without inflammation

Publication date: Available online 6 September 2019Source: Best Practice &Research Clinical RheumatologyAuthor(s): Jon LampaAbstractChronic pain is a common symptom in rheumatic diseases, and the patient with pain and no signs of inflammation poses a challenge to the physician.Notably, all rheumatic diseases have components of non-inflammatory pain and a higher prevalence of fibromyalgia compared to the overall population.Hypothetically, a chronic pain stimulus may have stronger impact in a chronic inflammatory state, and the process towards a pain condition may be influenced by individual predisposition for development of chronic pain. In addition, the features of peripheral and central pain processing may be exacerbated by inflammation, and disturbed pain processing may be a feature contributing to widespread pain.We herein review and describe the prevalence of chronic pain and different pain modalities in the most common rheumatic diseases. In addition, the background mechanisms of non-inflammatory pain in rheumatic diseases are discussed.Finally, we here review the current strategies for pain management, with a special focus on non-inflammatory pain. The key message is that pain management should be individualized and based on a thorough pain analysis with investigation of the pain modality, localization and pain intensity. Other factors to consider are the underlying rheumatic disease and treatment, the patient's mental and physical health status and psychological fa...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research

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Condition:   Patient With Chronic Neuropathic Pain and Fibromyalgia Intervention:   Drug: Lidocaine Hydrochloride 2% Intravenous Solution, DIN 02421992 Sponsor:   Allevio Pain Management Clinic Recruiting
Source: - Category: Research Source Type: clinical trials
In this study of 462 patients with SLE from the population-based Michigan Lupus Epidemiology and Surveillance (MILES) Cohort and 192 frequency-matched persons without SLE, nearly one third (31%) of SLE patients were using prescription opioids during the study period (2014-2015), compared with 8% of persons without SLE (p1 year, and 31 (22%) were concomitantly on two or more opioid medications. Among SLE patients, those using the emergency department (ED) were approximately twice as likely to use prescription opioids (odds ratio [OR] = 2.1; 95% confidence interval [CI] = 1.3-3.6; p = 0.004). In SLE, the ...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
Fibromyalgia (FM) is a chronic widespread musculoskeletal pain condition that predominantly affects women and interferes with individuals ’ daily functioning.58,80 Repeated activity interference can substantially limit one's successful adjustment to chronic pain through the development of negative self-schema and reduction of rewards that stem from engaging in meaningful and enjoyable activities.23,26 Hence, a central target of chro nic pain management is helping individuals increase their engagement in and performance of important daily activities.
Source: The Journal of Pain - Category: Materials Science Authors: Tags: Original Reports Source Type: research
AbstractPurpose of ReviewThis review discusses the recent advancements in research on Cannabinoids ’ role in pain, including its use in cancer pain, neuropathic pain, fibromyalgia, headache, visceral pain, postoperative and failed back pain management, and concurrent use with opioids.Recent FindingsCurrent research suggests that a potential role exists for medical cannabis in pain management, although research shows varied effectiveness by the type of pain. Moreover, its coadministration with opioids may result in reduced opioid requirements.SummaryPatients with neuropathic pain, cancer pain, and migraine headache ma...
Source: Current Emergency and Hospital Medicine Reports - Category: Emergency Medicine Source Type: research
DiscussionIn fibromyalgia patients, the effects of the BPS on the outcomes seem to be more related to changes in affect than to changes in future expectations.SignificanceThis is the first study to present evidence about who can benefit from an intervention designed to augment positive affect and promote positive functioning in FMS patients and how these changes occur. It extends previous findings on patient characteristics associated with the response to pain management interventions.
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Pain makes us human. It is a bell, fine-tuned by evolution, that often rings in moments necessary for our survival. Because of pain, we can receive warnings that trigger the reflexes to escape potential danger. But what happens when that bell continues to ring? How do we respond to a signal when it interferes with the other elements that make us human? Pain that lasts longer than six months is considered chronic, and it may not go away. With chronic pain, the bell’s ongoing signal gets your nervous system wound up and increases its reactivity to incoming messages. This can be quite distressing and anxiety-provoking. ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Back Pain Mind body medicine Pain Management Source Type: blogs
NEW YORK (Reuters Health)—Mindfulness-based stress reduction (MBSR) is more effective than treatment as usual for improving function and other outcomes in patients with fibromyalgia, according to a new randomized trial. MBSR is an extension of cognitive-behavioral therapy (CBT) intended to help patients change the way they experience symptoms, Dr. Albert Feliu-Soler of the Institut de... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Soft Tissue Pain Chronic pain Fibromyalgia mindfulness Pain Management patient care Source Type: research
Conclusions: Monitoring the affective dimension of pain should be included in an integrated approach to pain, and Hatha yoga may be beneficial in the pain management of FM participants. PMID: 31370034 [PubMed - in process]
Source: Advances in Mind Body Medicine - Category: Psychiatry Tags: Adv Mind Body Med Source Type: research
Publication date: Available online 17 July 2019Source: Best Practice &Research Clinical RheumatologyAuthor(s): Sizheng Steven Zhao, Stephen J. Duffield, Nicola J. GoodsonAbstractFibromyalgia (FM) is one of the most common conditions that rheumatologists encounter. It is characterised by chronic widespread pain, fatigue, sleep disturbances and impaired cognition. The prevalence of comorbid FM among populations with rheumatoid arthritis (RA), axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are considerably higher than among the general population, with pooled prevalence estimates of 18–24% in RA, 14&n...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
Abstract Juvenile fibromyalgia (JFM) is a chronic pain syndrome with onset in developmental age, characterized by widespread musculoskeletal pain associated with other neurological or nonneurological symptoms. Headache is one of the most frequent comorbid conditions with JFM, but this association is still poorly studied in the juvenile population. The literature review was conducted searching through PubMed, Scopus, and Web of Science with a combination of the following free-text terms: "fibromyalgia," "juvenile fibromyalgia," "headache," "primary headache," "migraine,&...
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
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