MiR-34a inhibits spinal cord injury and blocks spinal cord neuron apoptosis by activating phatidylinositol 3-kinase (PI3K)/AKT pathway through targeting CD47.
CONCLUSION: MiR-34a can downregulate CD47 expression to activate PI3K/AKT signal pathway, and thus inhibit SCI induced spinal neuron apoptosis.
PMID: 31490756 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - Category: Neurology Authors: Qi L, Jiang-Hua M, Ge-Liang H, Qing C, Ya-Ming L Tags: Curr Neurovasc Res Source Type: research