The effect of dextromethorphan use in Parkinson's disease: A 6-hydroxydopamine rat model and population-based study.
This study investigated the effect of dextromethorphan (DXM) against Parkinson's disease (PD) in rats and explored the association between DXM dose and PD risk in elderly patients 65 years and older using a population-based database. The PD rat model (Sprague Dawley rats) was induced by injecting 6-hydroxydopamine (6-OHDA) into the unilateral medial forebrain bundle of the rat brain. DXM (20 mg/kg) was administered intraperitoneally twice daily from 7 days before the appearance of a 6-OHDA lesion to 28 days after the lesion appeared. The availability of dopamine transporter (DAT) and serotonin transporter (SERT) in the striatum of the rat brain was measured using positron emission tomography. The apomorphine-induced rotation test was performed to study the hypersensitivity of the brain regions with lesions. This animal study demonstrated that DXM significantly attenuated 6-OHDA-induced DAT and SERT loss, correlating to rotational behaviors. The population-based human study analyzed the data from the Taiwan Longitudinal Health Insurance Database 2005 between January 2005 and December 2013 and then used the DXM dose-response curve to investigate the trend of its protective effect against PD. In the human study, low cumulative doses of DXM may potentially achieve a protective effect for PD; however, high cumulative doses seem to be a risk for PD. PMID: 31491406 [PubMed - as supplied by publisher]
Parkinson's disease is a heterogeneous disorder with both motor and non-motor symptoms that contribute to functional impairment. To develop effective, disease modifying treatments for these symptoms, biomarkers are necessary to detect neuropathological changes early in the disease course and monitor changes over time. Advances in MRI scan sequences and analytical techniques present numerous promising metrics to detect changes within the nigrostriatal system, implicated in the cardinal motor symptoms of the disease, and detect broader dysfunction involved in the non-motor symptoms, such as cognitive impairment.
Conclusion: Anti-CV2 autoimmune encephalitis can present as Parkinsonism with bilateral leukoencephalopathy on MRI. PET scanning can be useful to reveal an occult cancer. Treatment of the cancer may improve the paraneoplastic neurological syndrome without the need of immunosuppressive therapy.
Objective: To investigate the dynamic amplitude of low-frequency fluctuations (dALFFs) in patients with Parkinson's disease (PD) and healthy controls (HCs) and further explore whether dALFF can be used to test the feasibility of differentiating PD from HCs.Methods: Twenty-eight patients with PD and 28 demographically matched HCs underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans and neuropsychological tests. A dynamic method was used to calculate the dALFFs of rs-fMRI data obtained from all subjects. The dALFF alterations were compared between the PD and HC groups, and the correlations between dA...
To evaluate the mechanisms for restoring selective attention, it is advisable to study the network pattern of intercortical interaction with formation of executive cognitive functions of cluster ’s based on auditory evoked potentials (AEPs) mapping and positron emission tomography (PET-scan).
French researchers are developing what they say will be the most powerful magnetic resonance imaging (MRI) scanner in the world, which will use a supermagnet the weight of a blue whale and should allow earlier diagnosis of diseases such as Parkinson's.Reuters Health Information
Conditions: Parkinson Disease; GBA Gene Mutation; Gaucher Disease Interventions: Diagnostic Test: PET scan; Diagnostic Test: neuroQWERTY Sponsors: Pacific Parkinson's Research Centre; University of British Columbia; University of Washington; Oregon Health and Science University; Simon Fraser University; Michael J. Fox Foundation for Parkinson's Research; Silverstein Foundation; Weston Brain Institute Recruiting
French researchers are developing what they say is the most powerful Magnetic Resonance Imaging (MRI) scanner in the world which will use a supermagnet the weight of a blue whale and should allow earlier diagnosis of diseases such as Parkinson's.
oem B PMID: 31534023 [PubMed - as supplied by publisher]
In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial. People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
A new study has found that lefties ’ brains could be associated with better verbal skills, among other talents. I always knew I was specialBeing a leftie has a genetic component, is linked to better verbal skills and is associated with a lower risk of Parkinson ’s disease, according toa new study published in the journal Brain. Unfortunately for Guardian readers, that ’s leftie in the handedness sense, not political. Fortunately for me, I’m both.The study is a fascinating one, using thousands of brain scans and hundreds of thousands of sequenced genomes to look for associations between genes, brains...