The effect dioxidovanadium complex (v) on hepatic function in streptozotocin-induced diabetic rats.

The effect dioxidovanadium complex (v) on hepatic function in streptozotocin-induced diabetic rats. Can J Physiol Pharmacol. 2019 Sep 06;: Authors: Sibiya S, Msibi B, Khathi A, Sibiya N, Booysen I, Ngubane P Abstract Diabetics are susceptible hepatic dysfunction risks due to hyperglycaemia and insulin therapy. Diabetes conventional treatments improve glycaemic control, however hepatic hazards associated with these agents remains a challenge. Accordingly, this study sought to investigate the effect of a dioxidovanadium complex (V) on the hepatic function in STZ-induced diabetic rats. Sprague-Dawley rats (240-250g) were divided into 4 groups (n=6) namely, non-diabetic control, diabetic control, insulin treated and vanadium complex group. The dioxidovanadium (10, 20, 40 mg/kg) was administered twice every 2nd day for 5 weeks where blood glucose concentration was monitored weekly. At the end of the experimental period, all the experimental groups were sacrificed after which the lipid profile, liver superoxide dismutase (SOD), glutathione peroxidase (GPx) and malondialdehyde (MDA), plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and C reactive protein concentration were measured. The administration of dioxidovanadium significantly alleviated hyperglyceamia with concomitant attenuation in oxidative stress as evidenced by reduced MDA concentrations. Furthermore, vanadium complex abolished diabetes-induced dyslipid...
Source: Canadian Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Can J Physiol Pharmacol Source Type: research