Elevated serum alkaline phosphatase in epilepsy: Effect of age and treatment.
The objective of the present study was to investigate the effect of antiepileptic drug therapy on the hematobiochemical parameters in patients with epilepsy and to investigate the association of altered parameters with different demographic and clinical variables. Methods: A cross-sectional study involving 567 patients with epilepsy (drug-naive, N=223; phenytoin, N=85; carbamazepine, N=114; valproate, N=100; and multitherapy, N=45) and 37 healthy controls, aged 5-60 years, from North India was conducted. Hematological and biochemical profiling of all the subjects was performed at a single center. Results: Of all the parameters evaluated, only alkaline phosphatase (ALP) levels were found to be elevated in drug-free as well as patients on antiepileptic drug therapy. Early age and higher pretreatment seizure frequency were significantly associated with higher ALP levels (p
Authors: Husain AM Abstract [Box: see text]. PMID: 31608668 [PubMed - as supplied by publisher]
New research examines the role of KCC2, a transporter responsible for the discharge of chloride in cells, in developing disorders such as epilepsy and autism.
Condition: Drug Resistant Epilepsy Interventions: Other: mindfulness intervention; Other: psycho educative programme Sponsor: University Hospital, Grenoble Not yet recruiting
We present the case of a 12-year-old girl with medically refractory epilepsy and a vagal nerve stimulator (VNS), who experienced severe obstructive sleep apnea (OSA) with respiratory events closely matching her VNS settings. We demonstrated a real-time decrease in OSA through an in-laboratory VNS titration study, decreasing her VNS frequency from 20 Hz to 10 Hz. We were able to demonstrate a baseline level of OSA by turning off the VNS. We then effectively treated her residual OSA with continuous positive airway pressure (CPAP). Novel to our case is that this in-laboratory VNS titration did not result in any subsequent inc...
AbstractStiripentol (Diacomit®) is an orally-active, structurally unique anti-epileptic drug (AED) with multiple potential mechanisms of action, including enhancement of central γ-aminobutyric acid transmission. In the EU, stiripentol is indicated for use in conjunction with clobazam and valproate as adjunctive therapy of refractory generalized tonic-clonic seizures in patients with Dravet syndrome (DS; previously known as severe myoclonic epilepsy of infancy), whose seizu res are not adequately controlled with clobazam and valproate. This approval (and similar DS indications in the USA, Canada and Japan), reflec...
ConclusionsAll patients with severe autism had SPAs. However, they did not correlate with FDG-PET findings.
In this study, the mean phase coherence index was used as a reliable indicator for identifying the pre-ictal period of 21-patient Freiburg dataset. In order to predict the seizures on-line, an adaptive Neuro-fuzzy model named ENFM (evolving Neuro-fuzzy model) was used to classify the extracted features. The ENFM was trained by a new class labeling method based on the temporal properties of a prediction characterized by two time intervals, seizure prediction horizon (SPH) and seizure occurrence period (SOP), which are subsequently applied in evaluation method. It is evident that increasing the SPH duration can be more benef...
Conclusions: In>8 years of observation, most participants experienced a robust and sustained antidepressant response to SCC DBS. News in Context: Ethical issues raised around deep brain stimulation (DBS) research Closing the Circuit: Helen Mayberg’s research could revolutionize depression treatment Expo Day: Neuroenginnering, BPI, Arrowsmith Program &ARPF from SharpBrains
ConclusionThis review confirms that healthcare professionals should discus SUDEP with CYPwE and/or their caregivers at or around the time of diagnosis and that the discussion should include prevalence of SUDEP, risk factors and risk reduction methods relative to the individual concerned. Apart from delivering SUDEP information face-to-face, with written or online information provided to reinforce messages, there is a lack of evidence on “how” to impart this sensitive information. Further research exploring the most acceptable and effective methods of discussing SUDEP with CYPwE and their caregivers is therefore indicated.
Autoimmune encephalitis should be considered when patients with posterior reversible encephalopathy syndrome show atypical clinical courses.