Total external ophthalmoplegia: First clinical manifestation of Sj ögren's syndrome.

Total external ophthalmoplegia: First clinical manifestation of Sjögren's syndrome. Strabismus. 2019 Sep 06;:1-5 Authors: Singh A, Mahesh M, Agrawal A, Kumar N, Verma R, Mittal SK, Kumar B Abstract Sjögren's syndrome (SS) is an autoimmune disease causing destruction of the exocrine glands secondary to lymphocytic infiltration. Common clinical symptoms of SS are xerostomia, xerophthalmia, myalgia, arthritis, and vasculitis. Neurological symptoms may precede the diagnosis of SS by up to 2 years in about 80% of patients. A 28-year-old female presented to us with complaints of horizontal and vertical diplopia along with inability to move the right eye and sudden drooping of the right upper eyelid. She was a recently diagnosed case of type 2 diabetes mellitus and had a history of foreign body sensation in both eyes for 4 months. Schirmers I test revealed less than 5 mm of wetting in both eyes after 5 min, suggesting dry eyes. On immunological blood investigations, serum c-peptide was normal, rheumatoid factor was negative, antinuclear antibodies were positive, and proliferating cell nuclear antigens were positive. Extractable Nuclear Ag profile RO 52 was strongly positive suggestive of primary SS. Lip biopsy revealed mild-to-moderate chronic inflammation showing irregular acanthotic epidermis, and dermis had perivascular lymphocytic infiltrate. Thus, the possible diagnosis of primary SS with type 2 diabetes mellitus and right-sided total external oph...
Source: Strabismus - Category: Research Tags: Strabismus Source Type: research

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Authors: Campos-Borges HC, Sanz-González SM, Zanón-Moreno V, Millán Salvador JM, Pinazo-Duran MD PMID: 31629562 [PubMed - as supplied by publisher]
Source: Archivos de la Sociedad Espanola de Oftalmologia - Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research
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Source: Life Sciences - Category: Biology Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
This article summarizes the milestones in the development of upadacitinib leading to this first approval for the treatment of rheumatoid arthritis.
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
The axis comprised by the Vasoactive Intestinal Peptide (VIP) and its G protein-coupled receptors (GPCRs), VPAC1, and VPAC2, belong to the B1 family and signal through Gs or Gq proteins. VPAC receptors seem to preferentially interact with Gs in inflammatory cells, rather than Gq, thereby stimulating adenylate cyclase activity. cAMP is able to trigger various downstream pathways, mainly the canonical PKA pathway and the non-canonical cAMP-activated guanine nucleotide exchange factor (EPAC) pathway. Classically, the presence of VPACs has been confined to the plasma membrane; however, VPAC1 location has been described in the ...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Regulated hemostasis, inflammation and innate immunity entail extensive interactions between platelets and neutrophils. Under physiological conditions, vascular inflammation offers a template for the establishment of effective intravascular immunity, with platelets providing neutrophils with an array of signals that increase their activation threshold, thus limiting collateral damage to tissues and promoting termination of the inflammatory response. By contrast, persistent systemic inflammation as observed in immune-mediated diseases, such as systemic vasculitides, systemic sclerosis, systemic lupus erythematosus or rheuma...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Therapy with Tyrosine Kinase Inhibitors (TKI) aiming stable deep molecular response is the gold standard to treat Chronic Myeloid Leukemia (CML). NKT-like cells (CD3+CD56+) combine characteristics of T and NK cells. The physiopathological role of these cells remains unknown although the literature refers their association with inflammation, autoimmune diseases, and cancer. Since the information regarding the role of NKT-like cells in CML is rare, we aimed at the characterization of these cells in CML patients treated with TKIs. Peripheral blood NKT-like cells from 48 CML patients and 40 healthy donors were analyzed by mult...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Diabetology International - Category: Endocrinology Source Type: research
Two UCLA professors, Dr. Denise Aberle and Dr. Carol Mangione, have been elected to the National Academy of Medicine, one of the highest honors in health and medicine.Aberle is a professor of radiology and bioengineering, and vice chair for research in the department of radiological sciences at theDavid Geffen School of Medicine at UCLA. Mangione is the Barbara A. Levey&Gerald S. Levey  Professor of Medicine and Public Health and chief of the division of general internal medicine and health services research. They were among 100 new members announced Oct. 21 during the academy’s annual meeting in Washington,...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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