Use of Guanfacine for Cannabis use Disorder and Related Symptomology.

CONCLUSIONS: Compared with former studies, we could not prove significant improvement in sleep or decrease of negative symptoms, but we found trends for increased positive mood symptoms. Our data did not show significant effects of guanfacine on withdrawal symptoms or craving. Due to early and longer cannabis use, our subjects indicate a great severity of illness increasing the likelihood of treatment resistance. SCIENTIFIC SIGNIFICANCE: On the basis of trends demonstrated here and other lines of evidence, further investigation is warranted regarding the utility of guanfacine as a potential treatment for CUD. (Am J Addict 2019;00:1-10). PMID: 31483544 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31483544?dopt=Abstract

Source: American Journal on Addictions - September 3, 2019 Category: Addiction Authors: Holst M, Mathai DS, Patel MM, Rodgman C, Keller J, Hussain MZ, De La Garza R, Kosten TR, Verrico CD Tags: Am J Addict Source Type: research