Identification of α-N-catenin as a novel tumor suppressor in neuroblastoma.

In conclusion, these data demonstrate that α-N-catenin is a tumor suppressor in non-MYCN-amplified neuroblastomas and it inhibits NF-κB signaling pathway to suppress tumor growth in human neuroblastomas. Therefore, restoring the expression of α-N-catenin can be a novel therapeutic approach for neuroblastoma patients who have the deletion of CTNNA2 and lack of MYCN amplification. PMID: 31489113 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/31489113?dopt=Abstract

Source: Oncotarget - September 7, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research