Is there an association between oocyte number and embryo quality? A systematic review and meta-analysis

Publication date: Available online 3 July 2019Source: Reproductive BioMedicine OnlineAuthor(s): Belinda G. Vermey, Su Jen Chua, Mohammad Hadi Zafarmand, Rui Wang, Salvatore Longobardi, Evelyn Cottell, Francois Beckers, Ben W. Mol, Christos A. Venetis, Thomas D'HoogheAbstractThe aim of this systematic review and meta-analysis was to determine the association between the number of oocytes aspirated after ovarian stimulation and the number of top/good quality embryos obtained in women undergoing ovarian stimulation for IVF/intracytoplasmic sperm injection (ICSI). MEDLINE, EMBASE, Scopus, CINAHL and Web of Science were searched for publications reporting on the number of top/good quality embryos at the cleavage (day 2/3) and/or blastocyst (day 5/6) developmental stage, and published in English up to 18 November 2017. Twenty-eight studies (three prospective and 25 retrospective) reporting data on 291,752 assisted reproductive technology (ART) cycles were considered eligible. We confirmed a strong positive association between the number of oocytes retrieved and the number of top/good quality day 2/3 embryos (weighted correlation coefficient [rw] = 0.791), day 5/6 embryos (rw = 0.901), metaphase II oocytes (rw = 0.988), oocytes exhibiting two pronuclei (rw = 0.987) and euploid embryos (rw = 0.851); P < 0.001 for all correlations (evaluated in subsets of the 17 studies with data enabling quantification of results). Data from 5657 cycles showed that the group...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research