Early Antibiotic Prophylaxis Prior to Bypass Surgery Improves Tissue Penetration.

CONCLUSIONS:  Early, additional preoperative administration of cefazolin was able to significantly increase peak tissue concentrations during surgery compared with the standard protocol. No difference, however, could be achieved in the percentage of time during which the concentration exceeded the MIC.
PMID: 31491791 [PubMed - as supplied by publisher]

Source: The Thoracic and Cardiovascular Surgeon - September 5, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Andreas M, Zeitlinger M, Shabanian S, Wisser W, Thell R, Edlinger-Stanger M, Maier-Salamon A, Jaeger W, Kocher A, Laufer G, Hiesmayr JM, Hutschala D Tags: Thorac Cardiovasc Surg Source Type: research