Perianal Crohn's Disease

This article provides an overview of the principles in the evaluation and management of perianal Crohn's disease (CD). Manifestation-specific treatment is addressed including abscess, fistula, skin tags, hemorrhoids, fissure, ulcers, strictures, ano-, and rectovaginal fistulas as well CD-associated hidradenitis suppurativa. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Clinics in Colon and Rectal Surgery - Category: Surgery Authors: Tags: Review Article Source Type: research

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Conclusions: Recurrent CA-CDI in children in our population is less common than previously reported. This study supports first-line treatment with the standard, short course metronidazole in most cases of primary CA-CDI.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
Publication date: Available online 17 October 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Katarzyna Bąk-Drabik, Piotr Adamczyk, Agata Chobot, Wojciech PluskiewiczSummaryPurposeTo assess the bone status in children with inflammatory bowel diseases (IBD) using quantitative ultrasound (QUS) measurement and dual-energy X-ray absorptiometry (DXA) at baseline and after two years of adequate treatment of the IBD and bone protection medication.MethodsSixteen children (six boys) with IBD, aged 13.4 ± 2.4 years, were examined at baseline and two years later. DXA was used to asses b...
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
Publication date: Available online 16 October 2019Source: International Journal of PharmaceuticsAuthor(s): Anastasia Foppoli, Alessandra Maroni, Saliha Moutaharrik, Alice Melocchi, Lucia Zema, Luca Palugan, Matteo Cerea, Andrea GazzanigaAbstract5-aminosalicylic acid (5-ASA) is the most widely used drug for the treatment of ulcerative colitis. The benefits of targeted delivery of 5-ASA to the large intestine are well known, resulting in reduced systemic absorption and increased local concentrations at the disease site. In the present study, a 5-ASA colon delivery system based on the time-dependent strategy, exploiting the r...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Condition:   Ulcerative Colitis Interventions:   Drug: GS-4875;   Drug: Placebo Sponsor:   Gilead Sciences Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Hidradenitis Suppurativa Interventions:   Other: Electronic Reporting;   Drug: Adalimumab Sponsor:   Wake Forest University Health Sciences Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Ulcerative Colitis;   Artificial Intelligence;   Confocal Laser Endomicroscopy Intervention:   Diagnostic Test: The diagnosis of Artificial Intelligence and endoscopist Sponsor:   Shandong University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Crohn's Disease;   IBD Interventions:   Drug: Infliximab;   Drug: Adalimumab Sponsors:   Children's Hospital Medical Center, Cincinnati;   The Leona M. and Harry B. Helmsley Charitable Trust Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Crohn Disease;   Ulcerative Colitis Interventions:   Drug: Amgevita 40Mg Solution for Injection;   Drug: HUMIRA 40Mg Solution for Injection Sponsor:   Fundación Pública Andaluza para la gestión de la Investigación en Sevilla Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study mainly investigated altered functional connectivity (FC) of the amygdala in CD patients during resting-state. Magnetic resonance imaging scans were acquired from 42 CD patients and 35 healthy controls (HCs). Whole amygdala bilaterally were selected as regions o f interest (ROIs). Voxel-based morphometry and FC methods were applied to investigate the differences of structure or intrinsic connectivity of the amygdala between the two groups, separately. Pearson correlations were performed to explore relationships between the clinical characteristics and neuro imaging findings in CD patients. Based on the whole...
Source: Brain Imaging and Behavior - Category: Neurology Source Type: research
Fibrosis is a significant complication of intestinal disorders associated with microbial dysbiosis and pathobiont expansion, notably Crohn’s disease (CD). Mechanisms that favor fibrosis are not well understood, and therapeutic strategies are limited. Here we demonstrate that colitis-susceptible Il10-deficient mice develop inflammation-associated fibrosis when monoassociated with adherent/invasive Escherichia coli (AIEC) that harbors the yersiniabactin (Ybt) pathogenicity island. Inactivation of Ybt siderophore production in AIEC nearly abrogated fibrosis development in inflamed mice. In contrast, inactivation of Ybt ...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Host Response and Inflammation Source Type: research
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