Spinal osteoid osteoma recurring as an aggressive osteoblastoma.

We report an uncommon case of osteoid osteoma recurring as an aggressive osteoblastoma of the spine. A 15-years-old male consulted in our department with long-term painful scoliosis. The CT-scans and MRI revealed a sclerotic bone forming tumor of 7mm diameter consistent with a osteoid osteoma. A percutaneous radiofrequency ablation was performed with complete resolution of the symptoms. After 6 months, the symptoms recurred. A new CT and a MRI showed a growth of the nidus on the right L4 lamina, with a size of 15mm. Therefore, a marginal resection by laminectomy of L4 was performed. Pathology confirmed an epithelioid osteoblastoma. A year later, subsequent imaging studies showed a new recurrence with aggressive features and invasion of the spinal canal. The patient then underwent an "in block surgery" needing concurrent stabilization of the spine. Histopathology confirmed the diagnosis of epithelioid osteblastoma. PMID: 31488355 [PubMed - as supplied by publisher]
Source: Neurocirugia - Category: Neurosurgery Authors: Tags: Neurocirugia (Astur) Source Type: research

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Publication date: Available online 24 February 2020Source: Annals of Medicine and SurgeryAuthor(s): mar A. Al-Mohrej, Sahar S. Aldakhil, Mohammed A. Al-Rabiah, Anwar M. Al-Rabiah
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
ConclusionThe reading on the ERC does not equate to the actual rod lengthening. The authors would recommend that clinicians using the MCGR for the treatment of early-onset scoliosis include pre- and post-extension imaging (radiographs or ultrasound) to confirm extension lengths at each outpatient extension. In centres with ultrasound facilities, we would suggest that patients should have ultrasound to monitor each lengthening after distraction but also 6-month radiographs.Graphic abstractThese slides can be retrieved under Electronic Supplementary Material.
Source: European Spine Journal - Category: Orthopaedics Source Type: research
Conditions:   Adolescent Idiopathic Scoliosis;   Osteogenesis Imperfecta Intervention:   Device: Scoliosis back brace Sponsors:   IRCCS Eugenio Medea;   National Research Council of Italy - IPCB;   Orthopedic Center " Biomedica Su Misura " (Brescia, Italy);   Orthopedic Center  " Labsan "  (Lecco, Italy);   Politecnico di Milano - DIG Department Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
A retrospective analysis was conducted to analyze the position of the aorta by MRI in patients with adult degenerative scoliosis.
Source: Journal of Orthopaedic Surgery and Research - Category: Orthopaedics Authors: Tags: Research article Source Type: research
"Spinal column deformity" includes conditions such as idiopathic juvenile scoliosis, congenital scoliosis, post-traumatic lesions and other spinal deformities such as kyphosis(Szopa and Domagalska-Szopa, 2017).People with many types of spinal deformities, reported a high incidence of dyspnea on exertion and reduced vital capacity (VC). There is a significant risk of mortality and death in people with untreated scoliosis (Lin et al., 2004).
Source: Journal of Bodywork and Movement Therapies - Category: Physiotherapy Authors: Tags: Prevention and Rehabilitation Source Type: research
Authors: Nambiar PN, Kumar S S, Menon R, Nair SS, Madhavilatha GK, Sundaram S PMID: 32077773 [PubMed - as supplied by publisher]
Source: Ophthalmic Genetics - Category: Opthalmology Tags: Ophthalmic Genet Source Type: research
This study aimed to determine the mechanism by which melatonin inhibits the proliferation of osteoblasts.Main methodsCell viability experiment, DNA fragment detection and alkaline phosphatase (ALP) activity assays were performed to determine the effects of melatonin on the proliferation, apoptosis and differentiation of osteoblasts. We used immunofluorescence to detect the expression of STIM1 in melatonin-treated osteoblasts. STIM1 interference was achieved using a specific siRNA, and a TRPC inhibitor was used to block the influx of Ca2+. The mRNA expression was determined by RT-qPCR, and protein levels were measured by We...
Source: Life Sciences - Category: Biology Source Type: research
We report a ten-year-old boy, born to unrelated parents, with early-onset severe global development delay due to novel EMC1 biallelic pathogenic variants. A truncating variant, p.(Tyr378*) and a missense variant, p.(Phe953Ser), located in exon 11 and 23 of EMC1 gene respectively, have been found by reanalysis of exome sequencing data. The proband's phenotype included several signs that overlap with the phenotype of previously reported patients, associating severe global developmental delay, abnormal ophthalmological examination, and postnatal slow-down of the head circumference growth. Some distinguishing clinical signs we...
Source: European Journal of Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Eur J Med Genet Source Type: research
This article summarizes the best available evidence interventions for preventing and managing cerebral palsy in 2019.Recent FindingsEffective prevention strategies include antenatal corticosteroids, magnesium sulfate, caffeine, and neonatal hypothermia. Effective allied health interventions include acceptance and commitment therapy, action observations, bimanual training, casting, constraint-induced movement therapy, environmental enrichment, fitness training, goal-directed training, hippotherapy, home programs, literacy interventions, mobility training, oral sensorimotor, oral sensorimotor plus electrical stimulation, pre...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
Spinal muscular atrophy (SMA) is among the most common monogenic causes of spinal motor neuron(SMN) degeneration with severely affected cases having a median survival of less than 2 years of age. Nusinersen (Spinraza) is a novel antisense oligonucleotide administered intrathecally for treatment of SMA. Most of these patients have scoliosis often treated by posterior fusion from T2 to sacrum making lumbar puncture challenging. Building on our prior experience in intrathecal catheter placement, we describe our initial experience with an image-guided approach to implantation of intrathecal catheters and subcutaneous ports in ...
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 38 Source Type: research
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