Zika circulation, congenital syndrome, and current guidelines: making sense of it all for the traveller

Purpose of review Zika virus (ZIKV) swept through the Americas and led to recognition of its neurotropism. Zika circulation elsewhere in the world, nonvector transmission including maternal–fetal/sexual/transfusion routes, and additional reports on congenital Zika syndrome (CZS) and Guillain–Barré syndrome (GBS) have been published. Recent findings In 2018–2019, ZIKV transmission occurred in Cuba, India, and is suspected to appear sporadically in other countries. Maternal–fetal ZIKV transmission appears to occur in about 26% of ZIKV-infected pregnant women. The US ZIKV Pregnancy and Infant Registry identified 6% of live births to have at least one ZIKV-associated birth defect; 9% had at least one neurodevelopmental abnormality; 1% had both. Infectious virus was rarely isolated from semen of ZIKV-infected male patients beyond day 38 after symptom onset. Brazilian blood donations had low ZIKV prevalence in 2015–2016; in the United States, screening donations was cost-effective only in the high mosquito season in Puerto Rico. Summary ZIKV transmission continues; many countries with competent mosquitoes are at risk. Transmission can occur without detection where surveillance is poor and laboratory capacity limited. Travelers are important sentinels. Variations exist among ZIKV strains and Aedes mosquitoes that influence competence for transmission. Maternal–fetal transmission results in significant rates of abnormality. Identification of infectious virus in s...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: TROPICAL AND TRAVEL-ASSOCIATED DISEASES: Edited by Christina Coyle Source Type: research