New Role For ECMO In Treating Patients With Cardiac Arrest And Profound Shock
Extracorporeal membrane oxygenation (ECMO), a procedure traditionally used during cardiac surgeries and in the ICU that functions as an artificial replacement for a patient's heart and lungs, has also been used to resuscitate cardiac arrest victims in Japan, Taiwan, and South Korea. Now, a novel study of this technique in the U.S. has been completed by researchers at the Perelman School of Medicine at the University of Pennsylvania, indicating a potential role for this intervention to save patients who are unable to be resuscitated through conventional measures...
This study provides a possible reason why genes carrying health risks have persisted in human populations. The second found evidence for multiple variants in genes related to ageing that exhibited antagonistic pleiotropic effects. They found higher risk allele frequencies with large effect sizes for late-onset diseases (relative to early-onset diseases) and an excess of variants with antagonistic effects expressed through early and late life diseases. There also exists other recent tangible evidence of antagonistic pleiotropy in specific human genes. The SPATA31 gene has been found under strong positive genomic sele...
Treatment of adult congenital heart disease (ACHD) patients who require heart transplantation (HT) remains challenging due to limited donors and high perioperative and wait-list mortality. Those patients with single ventricle physiology palliated with Fontan are at the highest risk of early mortality due to multi-organ involvement; in addition, few centers are capable of safely transplant them. We sought to evaluate trends and outcomes of HT in these patients.
Hypomagnesemia is commonly observed in heart transplant (HT) recipients treated with calcineurin inhibitors. Low serum magnesium (s-Mg) is associated with inflammation and disturbances in the regulation of vascular tone and endothelial function and has been implicated in the progression of atherosclerosis, potentially leading to worsening coronary heart disease, atrial and ventricular arrhythmias and sudden cardiac death. We therefore investigated the association between s-Mg and HT outcomes.
Failing Fontan circulation patients are one of the fastest growing cohorts with heart failure presenting to congenital programs. We sought to describe their outcomes by combining two databases.
Orthotopic heart transplantation (OHT) among adult congenital heart disease (ACHD) patients triggers debate as to optimal donor sizing. Outcomes related to donor-to-recipient size ratios have never been analyzed in the ACHD population.
This study tested the hypothesis that HF hospitalizations and resource utilization among ACHD patients in the United States are significantly increasing.
Cardiac resynchronization therapy (CRT) has been shown to shorten QRS duration (QRSd) and improve ejection fraction (EF) in adults with congenital heart disease (ACHD) and children with heart failure with reduced ejection fraction (HFrEF). It is not known whether CRT confers a survival benefit. We sought to determine whether CRT is associated with longer transplant-free survival after adjusting for patient factors.
Congenital heart disease (CHD) is associated with high early post-transplant mortality but improved long-term survival in comparison to the overall heart transplant population. We aimed to evaluate survival outcomes of ACHD in adult transplant recipient patients as specifically compared to ischemic (ICM) and dilated cardiomyopathy (DCM) groups. This was a retrospective analysis of the ISHLT Registry data.
In this study we aim to look at whether transport time or distance impacts survival rate of implanted ECMO patients.
Heart failure is a significant cause of morbidity and mortality in congenital heart disease patients especially for the subset whose right ventricle functions as the systemic ventricle. The physiological and molecular differences in the right ventricle (RV) and left ventricle (LV) lead to different abilities to adapt to adverse conditions and respond to pharmacological therapeutics. Currently data describing the molecular changes that occur in the systemic RV are lacking. Available animal models create an RV with volume and/or pressure overload however the LV remains at high pressure.