New Role For ECMO In Treating Patients With Cardiac Arrest And Profound Shock

Extracorporeal membrane oxygenation (ECMO), a procedure traditionally used during cardiac surgeries and in the ICU that functions as an artificial replacement for a patient's heart and lungs, has also been used to resuscitate cardiac arrest victims in Japan, Taiwan, and South Korea. Now, a novel study of this technique in the U.S. has been completed by researchers at the Perelman School of Medicine at the University of Pennsylvania, indicating a potential role for this intervention to save patients who are unable to be resuscitated through conventional measures...
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Heart Disease Source Type: news

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We report that the disruption of excitation-contraction coupling contributes to impaired force generation in the mouse model of Sod1 deficiency. Briefly, we found a significant reduction in sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity as well as reduced expression of proteins involved in calcium release and force generation. Another potential factor involved in EC uncoupling in Sod1-/- mice is oxidative damage to proteins involved in the contractile response. In summary, this study provides strong support for the coupling between increased oxidative stress and disruption of cellular excitation contraction mac...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Eighty five percent of congenital heart disease patients currently survive to adulthood due primarily to advancements in surgical treatments1. For these survivors with Adult Congenital Heart Disease (ACHD), heart failure (HF) remains the leading cause of death2. Thus, the number of ACHD patients requiring heart transplantation (HT) continues to grow, and with this growth has come improvements in outcomes. In 2009, Lamour et al. demonstrated a 1-year survival of 83% for non-Fontan congenital HT and 71% for patients with Fontan palliation3.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
In this study, we investigate mitochondrial energetics and mtDNA methylation in senescent cells, and evaluate the potential of humanin and MOTS-c as novel senolytics or SASP modulators that can alleviate symptoms of frailty and extend health span by targeting mitochondrial bioenergetics. Exercise versus the Hallmarks of Aging https://www.fightaging.org/archives/2018/06/exercise-versus-the-hallmarks-of-aging/ The paper I'll point out today walks through the ways in which exercise is known to beneficially affect the Hallmarks of Aging. The Hallmarks are a list of the significant causes of aging that I dis...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study indicates that frailty and other age-related diseases could be prevented and significantly reduced in older adults. Getting our heart risk factors under control could lead to much healthier old ages. Unfortunately, the current obesity epidemic is moving the older population in the wrong direction, however our study underlines how even small reductions in risk are worthwhile." The study analysed data from more than 421,000 people aged 60-69 in both GP medical records and in the UK Biobank research study. Participants were followed up over ten years. The researchers analysed six factors that could impa...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, a debate exists on whether aging is a disease in itself. Some authors suggest that physiological aging (or senescence) is not really distinguishable from pathology, while others argue that aging is different from age-related diseases and other pathologies. It is interesting to stress that the answer to this question has important theoretical and practical consequences, taking into account that various strategies capable of setting back the aging clock are emerging. The most relevant consequence is that, if we agree that aging is equal to disease, all human beings have to be considered as patients to be treat...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The distribution of panel reactive antibodies (PRA) in adults with congenital heart disease (CHD) and its impact on post-transplant outcomes have not been studied.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Studies suggest less than half of children with single ventricle (SV) heart disease supported with the Berlin Heart EXCOR Pediatric VAD survive to heart transplant, with support durations lasting fewer than 14 days. Studies have been small and limited to patients implanted prior to 2011. We sought to examine single ventricle outcomes in an updated cohort of SV children supported with the Berlin Heart EXCOR VAD.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Adults with congenital heart disease (ACHD) have traditionally been considered poor heart transplant candidates due to higher mortality peri-operatively. This early disadvantage may be counterbalanced by excellent survival past the first year after heart transplantation (HT). Yet, deciding which patients with ACHD will benefit most from HT remains challenging. In a contemporary cohort, we evaluated clinical outcomes in patients with ACHD compared to adults with ischemic (ICM)&nonischemic cardiomyopathy (NICM).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
The prognosis of symptomatic cardiac amyloidosis - either of light chain (AL) or transthyretin (ATTR) type - is poor. Heart transplantation (HTX) might improve prognosis, but, previous reports suggested unfavorable survival after HTX in this population compared to HTX recipients with other indications as ischemic or dilative heart disease. Here, we analyzed our single center experience regarding HTX for cardiac amyloidosis.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Patients with heterotaxy syndrome (HS) who undergo cardiac surgery for congenital heart disease (CHD) have worse non-transplant surgical outcomes versus those without HS. Outcomes after heart transplant (HT) for HS have not been studied. We aimed to study waitlist and HT outcomes in CHD with and without HS.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
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