New Role For ECMO In Treating Patients With Cardiac Arrest And Profound Shock
Extracorporeal membrane oxygenation (ECMO), a procedure traditionally used during cardiac surgeries and in the ICU that functions as an artificial replacement for a patient's heart and lungs, has also been used to resuscitate cardiac arrest victims in Japan, Taiwan, and South Korea. Now, a novel study of this technique in the U.S. has been completed by researchers at the Perelman School of Medicine at the University of Pennsylvania, indicating a potential role for this intervention to save patients who are unable to be resuscitated through conventional measures...
In conclusion, a debate exists on whether aging is a disease in itself. Some authors suggest that physiological aging (or senescence) is not really distinguishable from pathology, while others argue that aging is different from age-related diseases and other pathologies. It is interesting to stress that the answer to this question has important theoretical and practical consequences, taking into account that various strategies capable of setting back the aging clock are emerging. The most relevant consequence is that, if we agree that aging is equal to disease, all human beings have to be considered as patients to be treat...
The distribution of panel reactive antibodies (PRA) in adults with congenital heart disease (CHD) and its impact on post-transplant outcomes have not been studied.
Studies suggest less than half of children with single ventricle (SV) heart disease supported with the Berlin Heart EXCOR Pediatric VAD survive to heart transplant, with support durations lasting fewer than 14 days. Studies have been small and limited to patients implanted prior to 2011. We sought to examine single ventricle outcomes in an updated cohort of SV children supported with the Berlin Heart EXCOR VAD.
Adults with congenital heart disease (ACHD) have traditionally been considered poor heart transplant candidates due to higher mortality peri-operatively. This early disadvantage may be counterbalanced by excellent survival past the first year after heart transplantation (HT). Yet, deciding which patients with ACHD will benefit most from HT remains challenging. In a contemporary cohort, we evaluated clinical outcomes in patients with ACHD compared to adults with ischemic (ICM)&nonischemic cardiomyopathy (NICM).
The prognosis of symptomatic cardiac amyloidosis - either of light chain (AL) or transthyretin (ATTR) type - is poor. Heart transplantation (HTX) might improve prognosis, but, previous reports suggested unfavorable survival after HTX in this population compared to HTX recipients with other indications as ischemic or dilative heart disease. Here, we analyzed our single center experience regarding HTX for cardiac amyloidosis.
Patients with heterotaxy syndrome (HS) who undergo cardiac surgery for congenital heart disease (CHD) have worse non-transplant surgical outcomes versus those without HS. Outcomes after heart transplant (HT) for HS have not been studied. We aimed to study waitlist and HT outcomes in CHD with and without HS.
Myocarditis is an inflammatory heart disease which involves a large number of cytokine receptors. In order to identify potential key signalling cascades we screened a number of receptors by Western blot and found high expression of the interleukin-7 (IL-7) receptor- α (IL-7Rα). Since IL-7 is usually required for the development of B as well as T lymphocytes we wanted to determine the major cell type(s) expressing this receptor. Importantly, immune cells might be also a source of IL-7.
Right ventricular (RV) is a key driver of outcome in heart failure and pulmonary vascular disorders. Although the RV fails in response to an increased afterload, it has been shown to be affected in patients with left heart diseases in the absence of pulmonary hypertension (PH). Therefore, it is recommended to consider the RV and the pulmonary artery (PA) as a single unit, defined physiologically by RV-PA coupling. The aim of this study is to assess whether non-invasive RV-PA coupling may predict outcome in PAH and in LHD.
We describe the design and rationale of a prospective multicenter registry aimed at collecting clinical data to be compared with retrospective control data to measure changes in outcomes and utility for surgeons when 3D printed models are used for planning VAD placement.
Different groups have described an impaired activity of the growth hormone (GH) / insulin-like growth factor I (IGF-I) axis in chronic heart failure (CHF) and its relation to poor clinical status and outcome. Nonetheless, the role for GH as potential therapeutic tool in HF is still controversial. NT-proBNP levels have been used to identify HF patients and correlate with both disease severity and prognosis. We sought to investigate the cardiovascular effects of GH treatment in patients with CHF due to ischemic heart disease.