Central Sulcus Misfolding: Polarity Reversal of SSEP N20 Potential in "layered" Polymicrogyria.

Central Sulcus Misfolding: Polarity Reversal of SSEP N20 Potential in "layered" Polymicrogyria. Neurodiagn J. 2019 Sep 05;:1-7 Authors: Hale T, Knecht A, Barbarevech K, Yue Q Abstract Paradoxical cortical potential polarity of the upper extremity somatosensory evoked potential (SSEP) has been reported in cases of polymicrogyria (PMG) syndrome. To date, the pathophysiological basis of this electrophysiological aberration remains under investigation. Here we present a case of mild PMG that showed "layered" microgyri in the left frontoparietal cortices affecting both hand and foot sensorimotor areas. The SSEP recordings revealed an isolated polarity reversal of N20 from the dysplastic cortex. We postulate a central sulcus misfolding theory to explain the "positive" N20 potential recorded in the PMG cortex. PMID: 31487235 [PubMed - as supplied by publisher]
Source: The Neurodiagnostic Journal - Category: Neurology Tags: Neurodiagn J Source Type: research
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