ASAP Proteomic Profiling of Rhabdomyosarcoma-Derived Exosomes Yield Insights into Their Functional Role in Paracrine Signaling

Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.9b00157
Source: Journal of Proteome Research - Category: Biochemistry Authors: Source Type: research

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Conditions:   Desmoplastic Small Round Cell Tumor;   Rhabdomyosarcoma Interventions:   Drug: Prexasertib;   Drug: Irinotecan;   Drug: Temozolomide Sponsor:   Memorial Sloan Kettering Cancer Center Recruiting
Source: - Category: Research Source Type: clinical trials
Authors: Zhang Q, Wang J, Chen C, Kong Y, Yan H, Duan J, Wang C, Sha Y, Wen X, Wang C Abstract The present study aimed to investigate the effects of perfluorooctanoic acid (PFOA) on tumor cell migration, invasion and apoptosis by activation of the PI3K/AKT signaling pathway in human rhabdomyosarcoma (RMS). PFOA is a persistent, synthetic organic environment pollutant, which has been previously associated with multiple diseases, including cancer. The present study aimed to confirm whether PFOA can elicit cell growth in the RD subline of RBS. RD cells were treated with different concentrations of PFOA. Cell prolifera...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Luca Bergamaschi Stefano Chiaravalli Maria Luisa Sensi Maura Massimino Gabriella Sozzi Andrea Ferrari Adolescents and young adults (AYA) with rhabdomyosarcoma (RMS) form a subgroup of patients whose optimal clinical management and access to care remain a challenge and whose survival lacks behind that of children diagnosed with histologically similar tumors. Understanding the tumor biology that differentiates children from AYA-RMS could provide critical information and drive new initiatives to improve the final outcome. MicroRNA (miRNA) and gene expression profiling (GEP) was evaluated in a RMS cohort of 49 t...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
This study aimed to evaluate risk factors pertinent to OS and to propose an optimal treatment strategy. METHODS: Clinical data of patients with PIRMS treated at Beijing Tiantan Hospital and from the English-language literature between 1946 and 2018 were reviewed. A literature review was performed via Ovid, MEDLINE, Embase, PubMed, Web of Science, and Cochrane databases using the terms "rhabdomyosarcoma," "intracranial," "cerebral," and "brain." Previously published data were processed and used according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidel...
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
Spindle cell rhabdomyosarcoma (RMS) is an aggressive sarcoma type with a predilection for the head and neck and frequent transactivating MYOD1 mutations. Malignant peripheral nerve sheath tumors (MPNST) show heterologous (most often rhabdomyoblastic) differentiation in 10% of cases; such tumors have been referred to as malignant “Triton” tumors. MPNST frequently harbors inactivating mutations in SUZ12 or EED, resulting in PRC2 dysfunction and loss of histone H3 lysine 27 trimethylation (H3K27me3), most often seen in sporadic and radiation-associated, high-grade tumors; immunohistochemistry (IHC) for H3K27me3 is...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
Finding a career path in biomedical research can be challenging for many young people, especially when they have no footsteps to follow. We asked three recent college graduates who are pursuing advanced degrees in biomedical sciences to give us their best advice for undergrads. Tip 1: Talk with mentors and peers, and explore opportunities. One of the most challenging things for incoming undergraduates is simply to find out about biomedical research opportunities. By talking to professors and peers, students can find ways to explore and develop their interests in biomedical research. Credit: Mariajose Franco. Ma...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - Category: Research Authors: Tags: Being a Scientist Profiles Training Source Type: blogs
This article is protected by copyright. All rights reserved. PMID: 31508857 [PubMed - as supplied by publisher]
Source: Cell Biology International - Category: Cytology Authors: Tags: Cell Biol Int Source Type: research
AbstractPurpose of ReviewWe aim to review the most recent findings in the use of NK cells in childhood cancers.Recent FindingsNatural killer cells are cytotoxic to tumor cells. In pediatric leukemias, adoptive transfer of NK cells can bridge children not in remission to transplant. Interleukins (IL2, IL15) can enhance NK cell function. NK cell-CAR therapy has advantages of shorter life span that lessens chronic toxicities, lower risk of graft versus host disease when using allogeneic cells, ability of NK cells to recognize tumor cells that have downregulated MHC to escape T cells, and possibly less likelihood of cytokine s...
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research
The most frequent histological types of rhabdomyosarcoma (RMS) in children are embryonal (ERMS) and alveolar (ARMS) tumours. The majority of ARMS are characterized by the presence of PAX3/7-FOXO1 gene fusion a...
Source: Diagnostic Pathology - Category: Pathology Authors: Tags: Research Source Type: research
ConclusionOsseous metaplasia is rarely detected in the gastrointestinal tract with most cases reported in malignant lesions and only a few in benign polyps. It is also important to raise awareness of this clinical mimic of sarcoma for clinicians and pathologists to properly diagnose and treat such cases.
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
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