Docking ‐based approach for identification of mutations that disrupt binding between Bcl‐2 and Bax proteins: Inducing apoptosis in cancer cells

ConclusionSeveral methods like PolyPhen ‐2, SIFT, and OncoKB have been developed to predict cancer‐associated or deleterious mutations, but no method is available to predict apoptosis‐inducing mutations. Thus, in this study, we have examined the mutations in Bcl‐2 and Bax proteins that disrupt their binding, which is crucial for i nducing apoptosis to eradicate cancer. This study suggests that protein–protein docking methods can play a significant role in the identification of hotspot mutations in Bcl‐2 or Bax that can disrupt their binding with wild‐type partner to induce apoptosis in cancer cells.

Source: Molecular Genetics & Genomic Medicine - September 5, 2019 Category: Genetics & Stem Cells Authors: Pawan Kumar Raghav, Rajesh Kumar, Vinod Kumar, Gajendra P. S. Raghava Tags: ORIGINAL ARTICLE Source Type: research