Squamous cell carcinoma of the renal pelvis presenting as an integumentary neoplasm of the flank: A case report

We report a 54-year-old man who presented with a 1-month history of an enlarged skin mass on the right flank. Diagnoses: The patient was subsequently diagnosed with metastatic SCC involving the patient's integumentary system near the flank region proximal to the right kidney following percutaneous nephrostomy. Interventions: The skin mass and the surrounding muscle tissue of the right flank were excised with a wide resection margin including radial nephrectomy. The soft tissue defect after resection was reconstructed using a unilateral gluteus maximus myocutaneous V-Y advancement flap. Outcomes: No recurrence of the SSC was found on follow-up CT performed 12 months postoperatively. Lessons: In patients with long-standing nephrolithiasis complicated by staghorn stone-related infections, biopsies from suspicious lesions detected during percutaneous nephrolithotomy may facilitate early diagnosis. The modified gluteus maximus V-Y advancement flap may be a useful technique for the reconstruction of extensive soft-tissue defects involving the flank region.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Related Links:

In this study, we identified reliable miRNA clusters that can be used to subclassify HNSCC tumors as well as other squamous tumors of other anatomic locations. An institutional discovery cohort was generated using miRNA expression data from microarrays, and this was validated using publicly available next-generation microRNA sequencing data from TCGA. Further analysis of these subtypes revealed distinct biological and clinical features of HNSCC tumors based on the miRNA expression profiles, which provides new insights into the pathogenesis and treatment of HNSCC.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens synthetic construct Source Type: research
Series Type : Non-coding RNA profiling by array ; Expression profiling by arrayOrganism : Rattus norvegicusThis SuperSeries is composed of the SubSeries listed below.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Expression profiling by array Rattus norvegicus Source Type: research
Contributor : Kohei MatsushitaSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusCompensation is a physiological response that occurs during chemical exposure to maintain homeostasis. Because compensatory responses are not usually considered adverse effects, it is important to understand compensatory mechanisms for chemical risk assessment. Although the kidney is a major target organ for toxicity, there is controversy over whether hyperplasia or hypertrophy contributes to the compensatory mechanism, and there is limited information to apply for chemical risk assessment. In the current study, compensator...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Source Type: research
Contributor : Kohei MatsushitaSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusCompensation is a physiological response that occurs during chemical exposure to maintain homeostasis. Because compensatory responses are not usually considered adverse effects, it is important to understand compensatory mechanisms for chemical risk assessment. Although the kidney is a major target organ for toxicity, there is controversy over whether hyperplasia or hypertrophy contributes to the compensatory mechanism, and there is limited information to apply for chemical risk assessment. In the current study, compensator...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Source Type: research
Contributor : Kohei MatsushitaSeries Type : Non-coding RNA profiling by arrayOrganism : Rattus norvegicusCompensation is a physiological response that occurs during chemical exposure to maintain homeostasis. Because compensatory responses are not usually considered adverse effects, it is important to understand compensatory mechanisms for chemical risk assessment. Although the kidney is a major target organ for toxicity, there is controversy over whether hyperplasia or hypertrophy contributes to the compensatory mechanism, and there is limited information to apply for chemical risk assessment. In the current study, compens...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Rattus norvegicus Source Type: research
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Other Homo sapiens Source Type: research
Contributors : Rosela Golloshi ; Rebeca San Martin ; Priyojit Das ; Delaney Thurston ; Trevor F Freeman ; Thomas I Raines ; Rachel P McCordSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe investigate the effect of constricted migration (using transwell assays with 5- μm or 12-μm in diamter) on the organization of the 3D genome in melanoma cells.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Rosela Golloshi ; Rebeca San Martin ; Priyojit Das ; Delaney Thurston ; Trevor F Freeman ; Thomas I Raines ; Rachel P McCordSeries Type : OtherOrganism : Homo sapiensWe investigate the effect of constricted migration (using transwell assays with 5- μm or 12-μm in diamter) on the organization of the 3D genome in melanoma cells.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Contributors : Rosela Golloshi ; Rebeca San Martin ; Priyojit Das ; Delaney Thurston ; Trevor F Freeman ; Thomas I Raines ; Rachel P McCordSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe investigate the effect of constricted migration (using transwell assays with 5- μm or 12-μm in diamter) on the organization of the 3D genome in melanoma cells.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Contributor : Johannes TextorSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCancer vaccines utilizing naturally circulating dendritic cell (DC) subsets, such as plasmacutoid DCs (pDCs) and type 2 convential DCs (cDC2s), have demonstrated their potential as a therapy. For melanoma in recent clinical trials. These DC vaccines aim to. human. DC subsets on the. T cell transcriptional program, which. forms the. molecular. basis. of an. antitumor. T cell response, is. poorly understood. In. this study, we investigated the eraly gene expressionsignature of CD8+ T. cells following. stimulati...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
More News: Cancer & Oncology | Carcinoma | Gastroschisis Repair | Hepatocellular Carcinoma | Internal Medicine | Kidney Stones | Lessons | Liver | Liver Cancer | Nephrectomy | Pyelonephritis | Skin | Skin Biopsy | Skin Cancer | Squamous Cell Carcinoma | Study | Ureter and Renal Pelvis Cancer | Urology & Nephrology