Endocarditis and bacterial brain abscess in a young woman with a single atrium, patent ductus arteriosus, and Eisenmenger syndrome: A case report

We reported a 35-year-old woman with a single atrium, patent ductus arteriosus, pulmonary hypertension, and ES who developed infective endocarditis on her left ventricular outflow tract and complicated cerebral abscess and who underwent challenged medical treatment. Intervention: Infection was successfully controlled after 4-time change in antibiotics over 4 months. However, surgery is complicated for her. Outcomes: The patient presented a relatively good outcome during follow-up for>6 months. Lessons: This case report suggests that patients with complex CHD should accept surgery therapy earlier before developing ES. It is imperative to avoid invasive interventions to prevent infectious endocarditis.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

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ConclusionsThe data regarding ketamine use in mechanically ventilated patients is limited in terms of quantity, methodological quality, and demonstrated clinical benefit. Ketamine may play a role as a sedative-sparing agent, but may be associated with harm. High-quality studies are needed before widespread adoption of ketamine earlier in the sedation pathway.
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
ConclusionThis study indicates that the antihypertensive activity of P. niruri extract is mediated by vasoactive phytoconstituents that dilate the arterial wall via endothelium-dependent pathways and β-adrenoceptor activity which, in turn, cause vasorelaxation and reduce blood pressure.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 5 November 2019Source: Indian Heart JournalAuthor(s): Sreenivas Reddy, Suraj Kumar, Jeet Ram Kashyap, Raghavendra Rao, Vikas Kadiyala, Hithesh Reddy, Naindeep Kaur, Vadivelu Ramalingam, Jaspreet KaurAbstractObjectiveThe coronary artery dimensions have important diagnostic and therapeutic implications in management of coronary artery disease (CAD). There is paucity of data on the coronary artery size in the Indian population as measured by intravascular ultrasound (IVUS).MethodsA total of 303 patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) wi...
Source: Indian Heart Journal - Category: Cardiology Source Type: research
Publication date: Available online 10 December 2019Source: Canadian Journal of CardiologyAuthor(s): Laurie W. Geenen, Vivan J.M. Baggen, Annemien E. van den Bosch, Jannet A. Eindhoven, Robert M. Kauling, Judith A.A.E. Cuypers, Jolien W. Roos-Hesselink, Eric BoersmaAbstractBackgroundSingle high-sensitivity troponin T (hs-TnT) measurement is predictive of cardiac events in adults with congenital heart disease (ACHD). We aimed to study the prognostic value of serial hs-TnT measurements in stable ACHD patients.MethodsIn total, 602 consecutive ACHD patients were enrolled in this prospective study (2011-2013). Blood sampling was...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
This study analyzed whether calpain-1 causes cardiac hypertrophy and dysfunction by modulating the expression and activity of MMP-2 in renovascular hypertension.Main methodsMale Wistar rats were submitted to two kidneys, one clip (2K1C) model of hypertension or sham surgery and were treated with verapamil (VRP, 8 mg/kg/bid) by gavage from the second to tenth week post-surgery. Systolic blood pressure (SBP) was weekly assessed by tail-cuff plethysmography and morphological and functional parameters of LV were analyzed by echocardiography. MMP-2 activity was analyzed by in situ and gelatin zymography, while calpain-1 activ...
Source: Life Sciences - Category: Biology Source Type: research
This study focused on the role of Ulinastatin (UTI) in the anti-oxidative stress and anti-inflammatory response of cardiomyocytes. H9c2 cells were divided into control group, ischemia-anoxic group (ischemic hypoxia group) and ischemia-anoxia + UTI group (UTI group). Cell morphology was observed by light microscopy, Cell staining, Western blotting, quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA) were conducted to research the effect of UTI on the nuclear factor-κB (NF-κB) signaling pathway. H9c2 cells in the ischemic hypoxia group showed hypertrophy and ir...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
This Medicine MCQ Test Series contains 20 questions which can be attempted over 40 seconds each. After submission, answers and discussion will be displayed. Medicine MCQ Test Series 1 Time limit: 0 Quiz-summary 0 of 20 questions completed Questions: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Information ...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Medicine MCQ - CVS Source Type: blogs
Abstract Congenital coronary artery fistulas (CAFs) are infrequent congenital coronary artery anomalies. Complications such as left‐to‐right shunt, congestive heart failure, myocardial infarction, pericardial effusion, aneurysm formation, rupture, hemopericardium, pulmonary hypertension, infective endocarditis (IE), syncope, stroke, and sudden death may occur with a variable low frequency. To describe the clinical characteristics of patients with CAFs complicated by IE. A search was conducted through PubMed using the terms “CAFs” and “IE.” Papers with a full description of the fistula characteri...
Source: Congenital Heart Disease - Category: Cardiology Authors: Tags: Review Article Source Type: research
This study found that though it is often associated with coronary artery disease (CAD), it can also occur in those without significant CAD. It was not specifically associated with disease of right coronary artery disease. This cardioinhibitory response may be a manifestation of the Bezold-Jarisch reflex. Bezold-Jarisch reflex inhibits sympathetic activity (sympathetic withdrawal) and increases parasympathetic activity, resulting in bradycardia, which may be associated with vasodilatation, nausea and hypotension. Bezold-Jarisch has been described in the setting of inferior wall infarction and coronary angiography. Origin...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology MCQ Cardiology X-ray Featured Source Type: blogs
Conclusion: The pattern of AHD is similar to other studies in developing countries, with RHD being the most prevalent. There is a need for increased emphasis on primary prevention to reduce the burden of these diseases in the study area.
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
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