Benign prolapsing inflammatory rectal polyp with osseous metaplasia mimicking rhabdomyosarcoma botryioides

ConclusionOsseous metaplasia is rarely detected in the gastrointestinal tract with most cases reported in malignant lesions and only a few in benign polyps. It is also important to raise awareness of this clinical mimic of sarcoma for clinicians and pathologists to properly diagnose and treat such cases.
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research

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Authors: Gutta A, Gromski MA Abstract Post-polypectomy bleeding (PPB) is one of the most common complications of endoscopic polypectomy. There are multiple risk factors related to patient and polyp characteristics that should be considered. In most cases, immediate PPB can be effectively managed endoscopically when recognized and managed promptly. Delayed PPB can manifest in a myriad of ways. In severe delayed PPB, resuscitation for hemodynamic stabilization should be prioritized, followed by endoscopic evaluation and therapy once the patient is stabilized. Future areas of research in PPB include the risks of direc...
Source: Clinical Endoscopy - Category: Gastroenterology Tags: Clin Endosc Source Type: research
CONCLUSION: There is moderate- to very low-quality evidence supporting the use of tissue-engineered bone using MSC therapy in maxillary alveolar bone regeneration compared with conventional bone grafting without MSCs. PMID: 31532823 [PubMed - as supplied by publisher]
Source: International Journal of Oral and Maxillofacial Implants - Category: ENT & OMF Tags: Int J Oral Maxillofac Implants Source Type: research
The term hemolytic uremic syndrome (HUS) encompasses 3 different entities: typical HUS caused by a shiga toxin –producing Escherichia coli, primary atypical HUS (aHUS) resulting from the dysregulation of the complement alternative pathway, and secondary HUS caused by a variety of etiologies whose common characteristic is to induce diffuse endothelial damage leading to thrombotic microangiopathy (TMA). As s hown in Supplementary Table S1, the most common causes of secondary HUS are drugs, infections, autoimmune diseases, malignancies, and hematopoietic stem cell transplantation.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Controversies in Nephrology Source Type: research
Abstract Although significant advances have been made in synthetic nerve conduits and surgical techniques, complete regeneration following peripheral nerve injury (PNI) remains far from optimized. The repair of PNI is a highly heterogeneous process involving changes in Schwann cell phenotypes, the activation of macrophages, and the reconstruction of the vascular network. At present, the efficacy of MSC-based therapeutic strategies for PNI can be attributed to paracrine secretion. Exosomes, as a product of paracrine secretion, are considered to be an important regulatory mediator. Furthermore, accumulating evidence...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
In conclusion, we found osteoblastogenesis was reduced in an acidic environment, and ASIC2, ASIC3, and ASIC4 were most highly expressed in turn during osteoblastogenesis within acidic media. ASIC2 was the most abundantly expressed gene in human bone cells in OVF compared with the control. ASIC2 could be crucial in the pathogenesis of osteoporosis and could serve as a therapeutic target for antiosteoporotic therapies. PMID: 31531354 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conditions:   Desmoplastic Small Round Cell Tumor;   Rhabdomyosarcoma Interventions:   Drug: Prexasertib;   Drug: Irinotecan;   Drug: Temozolomide Sponsor:   Memorial Sloan Kettering Cancer Center Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Soft Tissue Sarcoma Adult;   Advanced Cancer Interventions:   Drug: Association of Nivolumab + Relatlimab;   Drug: Nivolumab Sponsors:   Institut Bergonié;   Bristol-Myers Squibb Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Chronic rhinosinusitis is a long-lasting medical condition, usually caused by infection or exposure to irritants, such as allergies, that affects one in seven American adults. Symptoms include nasal obstruction, nasal congestion, nasal drainage, loss of smell and taste, and facial pain and pressure. Some people with chronic rhinosinusitis also develop additional symptoms, such as asthma and nasal polyps, that are exacerbated by underlying allergies. A nasal polyp is a noncancerous tumor that grows from the lining of the nose or sinuses and affects the drainage system of the sinuses. While chronic rhinosinusitis is not a li...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Allergies Cold and Flu Drugs and Supplements Ear, nose, and throat Health Source Type: blogs
Severe sepsis (SS) in pediatric oncology patients is a leading cause of morbidity and mortality. We investigated the incidence of and risk factors for morbidity and mortality among children diagnosed with cancer from 2008 to 2012, and admitted with SS during the 3 years following cancer diagnosis. A total of 1,002 children with cancer were included, 8% of whom required pediatric intensive care unit (PICU) admission with SS. Death and/or multiple organ dysfunction syndrome occurred in 34 out of 99 PICU encounters (34%). Lactate level and history of stem-cell transplantation were significantly associated with the development...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Authors: Taylor CA, Shawlot W, Ren JX, Mukhopadhyay S Abstract Tissue-specific knockout mice are widely used throughout scientific research. A principle method for generating tissue-specific knockout mice is the Cre-loxP system. Here, we give a detailed description of the steps required to generate and validate tissue-specific knockout mice using the Cre-loxP system. The first protocol describes how to use gene targeting in mouse embryonic stem cells to generate mice with conditional alleles. Subsequent protocols describe how to recover Cre transgenic mice from cryopreserved sperm using in vitro fertilization and p...
Source: Current Protocols in Toxicology - Category: Toxicology Tags: Curr Protoc Toxicol Source Type: research
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