Long Noncoding Transcriptome in Chronic Obstructive Pulmonary Disease.
Long Noncoding Transcriptome in Chronic Obstructive Pulmonary Disease.
Am J Respir Cell Mol Biol. 2019 Sep 05;:
Authors: Devadoss D, Long C, Langley RJ, Manevski M, Nair M, Campos MA, Borchert G, Rahman I, Chand HS
Abstract
Chronic airway inflammation from recurring exposure to noxious environmental stimuli results in a progressive and irreversible airflow limitation and the lung parenchymal damage that characterizes Chronic Obstructive Pulmonary Disease (COPD). The large variability observed in the onset and progression of COPD is primarily driven by complex gene-environment interactions. The transcriptomic and epigenetic memory potential of lung epithelial and innate immune cells drive responses such as mucous hyperreactivity and airway remodeling, tightly regulated by various molecular mechanisms for which several candidate susceptibility genes have been described. However, the recently described noncoding RNA species, in particular the long noncoding RNAs (lncRNAs), may also have an important role in modulating the pulmonary responses to chronic inhalation of toxic substances and the development of COPD. This review outlines the features of lncRNAs reportedly implicated in regulating the airway inflammatory responses to cigarette smoke exposure and their possible association with COPD pathogenesis. As COPD continues to debilitate the increasingly aging population and contribute to higher morbidities and mortalities worldwide, sea...
Source: Am J Respir Cell Mol... - Category: Respiratory Medicine Authors: Devadoss D, Long C, Langley RJ, Manevski M, Nair M, Campos MA, Borchert G, Rahman I, Chand HS Tags: Am J Respir Cell Mol Biol Source Type: research
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