Factors associated with women ’s adherence to postpartum thromboprophylaxis

AbstractPostpartum low-molecular-weight heparin (LMWH) thromboprophylaxis is indicated for a substantial proportion of women. We assessed women ’s adherence to postpartum thromboprophylaxis and the factors associated with adherence. This retrospective cohort study was conducted at a university hospital during 2018. Parturients for whom a recommendation for LMWH prophylaxis was given at discharge from the maternity ward were contacted at t he end of the recommended post-discharge course of LMWH, and were invited to participate in a telephone survey. The main outcome measures were optimal (>  80%) and suboptimal adherence (<  80%) to LMWH administration, reasons for nonadherence, and views regarding LMWH, as assessed by an adaptedBeliefs about Medication Questionnaire. Overall, 250 women completed the questionnaire. The median recommended duration of post-discharge LMWH was 7 [5 –8] days. Suboptimal adherence was reported by 82 (32.8%); 45 (18.0%) women did not administer any LMWH dose following discharge and only 147 (58.8%) completed the full LMWH course. In multivariate analysis, patients’ perceptions of the necessity of LMWH [odds ratio (95% CI): 3.50 (2.12, 9.53), P = 0.002] and of the adequacy of the explanation given prior to discharge regarding LMWH technical administration [odds ratio (95% CI): 5.0 (2.33, 11.11), P <  0.001] were positively associated with optimal adherence. Nearly one-third of women prescribed postpartum LMWH thromboprophyla...
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research