Identification of novel phytocannabinoids from Ganoderma by label-free dynamic mass redistribution assay

ConclusionsIn this work, we identified four natural cannabinoids from two fungi: Ganoderma cochlear (Blume & T. Nees) Bres., Hedwigia and Ganoderma hainanense J.D. Zhao, L.W. Hsu & X.Q. Zhang. They exhibited structural and functional diversities. Our work confirms the presence of active ingredients in the Ganoderma species to CB1 and CB2, and this finding establishes connections between the fungi and the cannabinoid receptors, which will serve as a starting point to connect their beneficial effects to the endocannabinoid system. This research will also enrich the inventory of cannabinoids and phytocannabinoids from fungi. Yet due to some limitations of this work, further structure-activity relationship studies and mechanism investigation are warranted in future.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research