A Narrative Review of Lifestyle Factors Associated with Parkinson's Disease Risk and Progression.

A Narrative Review of Lifestyle Factors Associated with Parkinson's Disease Risk and Progression. Neurodegener Dis. 2019 Sep 05;:1-9 Authors: Nag N, Jelinek GA Abstract Parkinson's disease is a complex slowly progressive neurodegenerative disorder with motor and non-motor symptoms affecting daily living. Despite effective symptomatic treatments, with various degrees of side effects, no disease-modifying therapeutic options presently exist. Symptoms progress, with an accumulating burden, reducing the quality of life and forming the impression that medications are no longer effective. Adopting positive lifestyle behaviours can empower patients, improve the quality of life, alleviate symptoms, and potentially slow disease progression. Lifestyle behaviours including nutrition, cognitive enrichment, physical activity, and stress management have beneficial effects on brain health and quality of life. While some evidence of an association of lifestyle with Parkinson's disease risk and progression exists, the sparse and often conflicting data make it difficult to provide clinical recommendations. Herein, we highlight studies showing promising associations between lifestyle and Parkinson's disease. Given the increasing aging of populations worldwide and the prevalence of neurological disorders, further research into self-management through adoption of positive lifestyle behaviours is clearly warranted to better enable individualized care. PMID: 31487721 [Pub...
Source: Neuro-Degenerative Diseases - Category: Neurology Authors: Tags: Neurodegener Dis Source Type: research

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Conclusion The patients in the DAT-positive group might have prodromal symptoms that were worsened by neuroleptic drugs. The results of detailed history-taking and neurological findings seem to indicate cases of compromised dopaminergic transmission before the administration of neuroleptic drugs. PMID: 32062624 [PubMed - in process]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conclusion: More data concerning the safety of antiparkinsonian drugs in PD treatment, as well as the effect of pregnancy on parkinsonian symptoms are needed. According to the current state of the art, L-DOPA therapy should be considered preferable to other drugs during pregnancy.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Condition:   Parkinson Disease Intervention:   Device: Auditive cueing Sponsors:   Ceriter Nederland BV;   Ziekenhuis Oost Limburg (ZOL) Hospital Genk, Belgium Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Parkinson Disease Intervention:   Drug: Lithium Sponsor:   University at Buffalo Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Parkinson Disease;   Cognitive Impairment, Mild;   Speech Interventions:   Diagnostic Test: Cognitive Battery;   Behavioral: Voice, Speech and Language Analysis;   Behavioral: Questionnaires and Clinical Assessments;   Genetic: DNA Analysis Sponsors:   University of Massachusetts, Worcester;   Sonde Health, Inc.;   Massachusetts Institute of Technology/Lincoln Labs;   Boston University;   VA Puget Sound Health Care System Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Parkinson Disease Intervention:   Drug: Lithium Sponsor:   University at Buffalo Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Parkinson Disease;   Cognitive Impairment, Mild;   Speech Interventions:   Diagnostic Test: Cognitive Battery;   Behavioral: Voice, Speech and Language Analysis;   Behavioral: Questionnaires and Clinical Assessments;   Genetic: DNA Analysis Sponsors:   University of Massachusetts, Worcester;   Sonde Health, Inc.;   Massachusetts Institute of Technology/Lincoln Labs;   Boston University;   VA Puget Sound Health Care System Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Parkinson Disease Intervention:   Device: Auditive cueing Sponsors:   Ceriter Nederland BV;   Ziekenhuis Oost Limburg (ZOL) Hospital Genk, Belgium Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 17 February 2020Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Zhike Zhou, Yifan Liang, Xiaoqian Zhang, Junjie Xu, Jueying Lin, Rongwei Zhang, Kexin Kang, Huiling Qu, Chuansheng Zhao, Mei ZhaoAbstractBackgroundThe aim of this meta-analysis is to evaluate the association of fibrinogen with risk of dementia and its subtypes.MethodsEmbase, Pubmed and Web of Science were retrieved systematically up to February 2019. Standard mean difference (SMD) with 95% confidence intervals was estimated using random-effects models.ResultsSixteen studies involving 3,649 participants were summariz...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
For a variety of sporadic neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis, it is well-established that ethnicity do affect the disease phenotypes. However, how the ethnicity could contribute to the clinical symptoms and disease progressions in monogenetic disorders, such as spinocerebellar ataxia type 3 (SCA3), remains less studied.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
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