Vitamin D as a Potential Agent for Ischemic Axonal Regeneration after Epineurial Devascularization of the Sciatic Nerve.

In this study it was aimed to investigate the effect of vitamin D3 after epineurial devascularization of the sciatic nerve. Forty adult female Wistar rats were randomly divided into four groups: Group 1 (Control), Group 2 (Sham-operated), Group 3 (Epineurial devascularization + vitamin D3 treatment), Group 4 (Epineurial devascularization + vehicle treatment). Recovery of the sciatic nerve was analyzed by functional (sciatic functional index, pinch test and biochemical analyses) and morphological (electron microscopic analysis and wet muscle weight analysis) methods. Comparison of the data revealed that vitamin D3 administration had a beneficial effect on regeneration after epineurial devascularization. We suggest that vitamin D3 is an effective agent in prevention of ischemic peripheral nerve insults. PMID: 31486754 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - Category: Neurology Authors: Tags: Curr Neurovasc Res Source Type: research