Postischemic fish oil treatment restores dendritic integrity and synaptic proteins levels after transient, global cerebral ischemia in rats

Publication date: Available online 6 September 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Daniela Velasquez de Oliveira, Tuany Caroline Bernardi, Silvana Regina de Melo, Jacqueline Godinho, Rúbia Maria Weffort de Oliveira, Humberto MilaniAbstractWe previously found that fish oil (FO) facilitated memory recovery in the absence of pyramidal neuron rescue after transient, global cerebral ischemia (TGCI). Fish oil preserved the expression of microtubule-associated protein 2 (MAP-2), suggesting a relationship between dendritic plasticity and memory recovery that is mediated by FO after TGCI. The present study examined whether postischemic treatment with FO prevents ischemia-induced loss of dendritic processes in remaining pyramidal neurons. The effects of FO on neuroplasticity-related proteins were also examined after TGCI. Rats were subjected to TGCI (15 min, four-vessel occlusion model) and then received vehicle or FO (300 mg/kg docosahexaenoic acid) once daily for 7 days. The first dose was administered 4 h postischemia. Golgi-Cox staining was used to evaluate dentrict morphology in the pyramidal neurons of hippocampus (CA1 and CA3 subfields) and prefrontal cortex (PFC). Neuronal nuclei protein (NeuN), brain-derived neurotrophic factor (BDNF), growth-associated protein 43 (GAP-43), synaptophysin (SYP), and postsynaptic density protein 95 (PSD-95) levels were measured by Western blot in both structures. Fifteen minutes of TGCI reduced cons...
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research

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Publication date: Available online 9 December 2019Source: Journal of Physics and Chemistry of SolidsAuthor(s): Cristina Crupi, Giovanni Carini, Giuseppe Carini, Mauro Federico, Andrea Mandanici, Valentino Romano, Giovanna D'AngeloAbstractStructural changes of (Ag2O)x(B2O3)1-x glasses, over the range between X = 0.0 and X = 0.14, have been monitored by Raman spectroscopy. Low temperature heat capacity measurements have been also performed between 0.4 K and 25 K to investigate along with low frequency Raman scattering the behavior of the low-energy vibrational dynamics. A progressively decreasing intensity of the...
Source: Journal of Physics and Chemistry of Solids - Category: Physics Source Type: research
Authors: Ring B, Burbank AJ, Mills K, Ivins S, Dieffenderfer J, Hernandez ML Abstract Objectives: Objective measurements of asthma impairment could aid teens in recognition of changes in asthma status over time. Ready access to a conventional spirometer is not realistic outside of the clinical setting. In this proof-of-concept study, we compared the performance of the VitalFlo mobile spirometer to the nSpire KoKo® sx1000 spirometer for accuracy in measuring Forced Expiratory Volume in one second (FEV1) and Forced Vital Capacity (FVC) in adolescents with asthma.Methods: Two hundred forty pulmonary function measu...
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Authors: Brignardello-Petersen R PMID: 31810520 [PubMed - as supplied by publisher]
Source: Journal of the American Dental Association - Category: Dentistry Tags: J Am Dent Assoc Source Type: research
Authors: Brignardello-Petersen R PMID: 31810519 [PubMed - as supplied by publisher]
Source: Journal of the American Dental Association - Category: Dentistry Tags: J Am Dent Assoc Source Type: research
Lawrence Mehren intends to retire as president and CEO of Tucson-based Accelerate Diagnostics Inc., effective Jan. 31, 2020. According to a U.S. Securities and Exchange Commission filing, Mehren will also give up his seat as a director of the publicly traded company, but will take on a part-time role with the medical diagnostics company immediately after his retirement. Mehren will be replaced as CEO by Jack Phillips, currently the company's chief operating officer, effective Feb. 1. Phillips,…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02467K, PaperLuis R. Domingo, Mar Rios-Gutierrez, Patricia Perez The enhanced reactivity of a series of four aza aromatic compounds (AACs) participating in the Diels-Alder (DA) reactions with ethylene has been studied within the Molecular Electron Density Theory (MEDT).... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02415H, PaperXiahe Chen, Qunmin Wang, Hai-Min Shen, Guijie Li, Yun-Fang Yang, Yuan-Bin She The mechanism and origins of stereoselectivity of asymmetric benzylic C –H hydroxylation by Ru-porphyrin were elucidated with density functional theory calculations. The reaction proceeds via a hydrogen-atom abstraction/oxygen-rebound pathway, wherein a... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
[Radio Dabanga] Kassala -Dengue fever rates in Kassala last week recorded a marked decline, ranging from 36 to 90 cases per day.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[Radio Dabanga] Khartoum -On Thursday, a large medical convoy left the Sudanese capital, heading to the Nuba Mountains in South Kordofan where it will offer free treatment to the victims of war in the region.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[Daily Maverick] The Helen Suzman Foundation makes a case for the National Health Insurance Bill to be withdrawn.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
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