Amniotic Membrane in Carpal Tunnel Syndrome

Condition:   Carpal Tunnel Syndrome Intervention:   Other: Amniotic membrane transplantation Sponsors:   Instituto de Oftalmología Fundación Conde de Valenciana;   National Council of Science and Technology, Mexico Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Publication date: Available online 30 July 2019Source: Molecular Genetics and MetabolismAuthor(s): A. Broomfield, J. Davison, J. Roberts, C. Stewart, P. Hensman, C. Beesley, K. Tylee, S. Rust, B. Schwahn, E. Jameson, S. Vijay, S. Santra, S. Sreekantam, U. Ramaswami, A. Chakrapani, J. Raiman, M.A. Cleary, S.A. JonesAbstractThe outcome of 110 patients with paediatric onset mucopolysaccharidosis II (MPS II) since the commercial introduction of enzyme replacement therapy (ERT) in England in 2007 is reported.Median length of follow up was 10 years 3 months (range = 1 y 2 m to 18 years 6 month). 78 patients were ...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
Hereditary transthyretin(TTR) ‐related amyloidosis (ATTRm amyloidosis) is an endemic/non‐endemic, autosomal‐dominant, early‐ and late‐onset, rare, progressive disorder, predominantly manifesting as length‐dependent, small fiber dominant, axonal polyneuropathy and frequently associated with cardiac disorders and other multisystem diseases. ATTRm amyloidosis is due to variants in theTTR gene, with the substitution Val30Met as the most frequent mutation.TTR mutations lead to destabilization and dissociation of TTR tetramers into variant TTR monomers, and formation of amyloid fibrils, which are consecutively deposi...
Source: Acta Neurologica Scandinavica - Category: Neurology Authors: Tags: REVIEW ARTICLE Source Type: research
AimTo characterize carpal tunnel syndrome (CTS) in patients with mucopolysaccharidosis I (MPS I). MethodData were included for patients with MPS I who had either nerve conduction examination that included a diagnosis of CTS or who had CTS release surgery. Although this represented a subset of patients with CTS in the MPS I Registry, the criteria were considered the most objective for data analysis. ResultsAs of March 2016, 994 patients were categorized with either severe (Hurler syndrome) or attenuated (Hurler–Scheie or Scheie syndromes) MPS I. Among these, 291 had a CTS diagnosis based on abnormal nerve conduction (...
Source: Developmental Medicine and Child Neurology - Category: Child Development Authors: Tags: Original Article Source Type: research
Children with Hurler syndrome (HS) develop carpal tunnel syndrome (CTS) owing to glycosaminoglycan deposition secondary to enzyme deficiency. Advancement in the treatment of the underlying enzyme deficiency now commonly includes peritransplant intravenous enzyme replacement therapy (ERT). The primary objective of this study was to determine if the use of limited ERT in addition to hematopoietic stem cell transplantation (HCT) for the treatment of children with HS reduces the incidence of surgical intervention for CTS compared with a cohort of historical controls treated with HCT alone.
Source: The Journal of Hand Surgery - Category: Surgery Authors: Tags: Scientific article Source Type: research
In October 2015, a 57-year-old Japanese man presented with a four-month history of slowly progressive neck pain, quadriplegia, and numbness of limbs. He had undergone hemodialysis for 30 years because of Alport syndrome until he received a kidney transplant 10 years previously. Nine years before, he underwent open carpal tunnel surgery for bilateral tunnel syndrome due to dialysis-related amyloidosis. Physical examination revealed a sensory deficit from the C6 dermatome downwards and motor dysfunction in the arms and legs.
Source: The American Journal of Medicine - Category: Journals (General) Authors: Tags: Clinical Communication to the Editor Source Type: research
Conclusions: FAP encountered in Crete is due to Met30 mutation. Haplotype analysis that is in progress may help elucidate the origin of this mutation in relation to other populations. Orthotopic liver transplantation is the most effective treatment currently available for this disabling polyneuropathy.Disclosure: Dr. Tzagournissakis has nothing to disclose. Dr. Spanaki has nothing to disclose. Dr. Amoiridis has nothing to disclose. Dr. Plaitakis has nothing to disclose. Dr. Mitsias has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Autonomic Disorders: Autonomic Neuropathies Source Type: research
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