Key Components of Engineering Vascularized Three-Dimensional Bioprinted Bone Constructs
Vascularization has a pivotal role in engineering successful tissue constructs. However, it remains a major hurdle of bone tissue engineering, especially in clinical applications for the treatment of large bone defects. Development of vascularized and clinically-relevant engineered bone substitutes with sufficient blood supply capable of maintaining implant viability and supporting subsequent host tissue integration remains a major challenge. Since only cells that are 100-200 µm from blood vessels can receive oxygen through diffusion, engineered constructs that are thicker than 400µm face a challenging oxygenation problem.
Source: Translational Research - Category: Research Authors: Fahimeh Shahabipour, Nureddin Ashammakhi, Reza Kazemi Oskuee, Shahin Bonakdar, Tyler Hoffman, Mohammad Ali Shokrgozar, Ali Khademhosseini Tags: Review Article Source Type: research
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