Iron overload and malignancies in patients with haemoglobinopathies: a single center experience

Thalassemias and sickle cell disease are a group of inherited blood disorders caused by alterations of the synthesis or of the structure of hemoglobin chains. It results in variable outcomes ranging from severe anemia to clinically asymptomatic individuals. Hemolysis and transfusions therapies lead to iron overload and, thus, to an high production of reactive oxygen species (ROS). Recently, it was found an increasing frequency of tumors in patients with hemoglobinopathies and it was underlined the probable role of iron overload in the carcinogenesis.
Source: Transfusion and Apheresis Science - Category: Hematology Authors: Source Type: research

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Conclusions: Fractal analysis may be used and recommended for evaluation of the bone changes induced by hemoglobinopathies.
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
This study reviews the current status of allo-HCT and autologous cellular therapies for SCD. Recent findings Alternative sources of allogeneic stem cells from unmatched donors such as cord blood and haploidentical donors are gaining traction. Early experience has shown that better conditioning regimens and graft-versus-host disease prophylaxis are needed before these donor sources can gain widespread use. Clinical trials are underway to determine the feasibility and efficacy of autologous transplantation with gene modified hematopoietic stem cells. Gene therapy strategies include HbS gene correction, gene addition, and ...
Source: Current Opinion in Hematology - Category: Hematology Tags: TRANSFUSION MEDICINE AND IMMUNOHEMATOLOGY: Edited by Steven L. Spitalnik Source Type: research
Condition:   Sickle Cell Disease Intervention:   Dietary Supplement: MitoQ Sponsor:   University of Pittsburgh Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Semionov A, Kosiuk J, Ajlan A, Discepola F Abstract Identification of certain abnormalities of the chest wall can be extremely helpful in correctly diagnosing a number of syndromic conditions and systemic diseases. Additionally, chest wall abnormalities may sometimes constitute diagnoses by themselves. In the present pictorial essay, we review a number of such conditions and provide illustrative cases that were retrospectively identified from our clinical imaging database. These include pentalogy of Cantrell, Klippel-Feil syndrome, cleidocranial dysplasia, Poland syndrome, osteopetrosis, neurofibromatosis ...
Source: Korean Journal of Radiology - Category: Radiology Tags: Korean J Radiol Source Type: research
Conclusions: the frequencies of infections in maternal-fetal health were considered low, highlighting on syphilis and the presence for sickle cell trait.Resumo Objetivos: estimar a taxa de detec ção de patologias da TPN em papel de filtro nas regiões Sul e Sudoeste do Estado da Bahia, bem como delinear o perfil epidemiológico dessas gestantes, calcular e estimar a taxa de adesão e abrangência de cobertura do Programa. Métodos: estudo descritivo, de agosto 2013 a agosto de 2015, de d ados obtidos do Labimuno/ICS/UFBA. Resultados: foram incluídas 64.743 gestantes; as m&e...
Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
Sickle cell anemiaSeptember is National Sickle Cell Awareness Month, which makes it a good time to learn more about the facts and signs of sickle cell anemia. It's an inherited form of anemia -- a condition in which there aren't enough healthy red blood cells to carry adequate oxygen throughout your body. For most people, [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news
Funding Opportunity RFA-HD-20-021 from the NIH Guide for Grants and Contracts. The purpose of this RFA is to encourage studies on reproductive health, fertility and fertility preservation/treatment options in patients born with a serious chronic condition who can now expect to survive into adulthood healthy enough to consider their reproductive health and fertility options. The underlying pathophysiology of diseases such as sickle cell anemia, thalassemia, and cystic fibrosis, among others, and/or the cumulative effects of their treatment, can compromise reproductive health. This RFA encourages teams of scientists with ex...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
AbstractVascular complications of sickle cell anemia (SCA) are influenced by many factors. Elevated plasma homocysteine (Hcy) is supposed to be an independent risk factor and is either genetic or nutritional origin. The present study evaluated the plasma Hcy level, MTHFR C677T gene polymorphism, effect of folic acid (FA) supplementation ‚ and hemato-biochemical parameters in SCA and their effect on the vaso-occlusive crisis (VOC) in SCA patients of an Asian-Indian haplotype population. One hundred twenty cases of SCA (HbSS) and 50 controls with normal hemoglobin(HbAA) were studied. It was found that the plasma Hcy le...
Source: Annals of Hematology - Category: Hematology Source Type: research
​Everyone who works with me knows that I love joint radiographs, and the wrist is my favorite. It was no surprise when I came on shift that someone exclaimed, "I have an x-ray for you. I bet you will know exactly what it is! This 30-ish-year-old lady came in with atraumatic wrist pain."I did know exactly what it was. My eyes were drawn to the lucent lunate target. The patient was still in the ED, so I went to examine her hand. She had increased pain when I walked my fingers proximally down the metacarpal, which dipped into the carpal space. She was also not a fan of volar flexion or dorsiflexion. It made sense....
Source: Lions and Tigers and Bears - Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
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