Daily light and darkness onset and circadian rhythms metabolically synchronize hematopoietic stem cell differentiation and maintenance: The role of bone marrow norepinephrine, TNF and melatonin cycles

Hematopoietic stem and progenitor cells (HSPC) dynamically replenish the blood with new mature blood and immune cells with a finite lifespan, while maintaining and renewing the undifferentiated HSPC bone marrow (BM) reservoir. Long-term repopulating HSC (LT-HSC) are identified and characterized in preclinical experimental transplantation assays, based on their functional ability to home and to durably repopulate the bone marrow (BM) and blood with high levels of both myeloid and lymphoid cells. Short-term repopulating HSPC are metabolically active with high levels of reactive oxygen species (ROShigh), giving rise to myeloid biased differentiation and repopulation, while LT-HSC are mostly retained in the BM in a non-motile, quiescent, low reactive oxygen species (ROSlow) metabolic state [1,2].
Source: Experimental Hematology - Category: Hematology Authors: Tags: Review Source Type: research