Microglia Metabolic Breakdown Drives Alzheimer's Pathology.

Microglia Metabolic Breakdown Drives Alzheimer's Pathology. Cell Metab. 2019 Sep 03;30(3):405-406 Authors: Bennett FC, Liddelow SA Abstract Altered metabolic function is common in stressed immune cells, but alteration in brain microglia during neurodegeneration is not understood. In this issue, Baik et al. (2019) provide insight into microglial metabolism. They demonstrate a switch from oxidative phosphorylation to glycolysis following interaction with amyloid beta acutely, and breakdown in both pathways chronically. PMID: 31484050 [PubMed - in process]
Source: Cell Metabolism - Category: Cytology Authors: Tags: Cell Metab Source Type: research