Tumor-induced peripheral immunosuppression promotes brain metastasis in patients with non-small cell lung cancer

ConclusionsThe frequency of PD-L1+ myeloid cells correlated with the presence of brain metastases. Tumor-derived IL-6 was capable of inducing PD-L1+ myeloid cells in vitro, suggesting that monitoring of immunosuppressive factors in peripheral blood may identify new targets for therapeutic intervention in selected patients.

http://link.springer.com/10.1007/s00262-019-02384-y

Source: Cancer Immunology, Immunotherapy - September 4, 2019 Category: Cancer & Oncology Source Type: research