Possible binding of piperine in Mycobacterium tuberculosis RNA-polymerase and rifampicin synergism.

Possible binding of piperine in Mycobacterium tuberculosis RNA-polymerase and rifampicin synergism.
Antimicrob Agents Chemother. 2019 Sep 03;:
Authors: Murase LS, de Souza JVP, Meneguello JE, Seixas FAV, Hegeto LA, de Lima Scodro RB, Siqueira VLD, Caleffi Ferracioli KR, Cardoso RF
Abstract
The activity of rifampicin (RIF) and piperine (PIP) was evaluated at the relative transcript levels of 12 efflux pumps (EPs) and an additional mechanism was proposed behind the synergic interactions of PIP+RIF in Mycobacterium tuberculosis (Mtb). Autodock-v4.2.3 and Molegro-v6 programs were used to evaluate PIP binding in Mtb RNA polymerase (RNAP). A hypothesis has been raised that PIP interferes in Mtb growth through RNAP inhibition, differently from what was previously endorsed for EPs inhibition only.
PMID: 31481438 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - September 2, 2019 Category: Microbiology Authors: Murase LS, de Souza JVP, Meneguello JE, Seixas FAV, Hegeto LA, de Lima Scodro RB, Siqueira VLD, Caleffi Ferracioli KR, Cardoso RF Tags: Antimicrob Agents Chemother Source Type: research